Influence of perineural invasion in predicting overall survival and disease-free survival in patients With locally advanced gastric cancer

被引:44
作者
Aurello, Paolo [1 ]
Berardi, Giammauro [1 ]
Tierno, Simone Maria [1 ]
Vinciguerra, Gian Luca Rampioni [2 ]
Socciarelli, Fabio [2 ]
Laracca, Giovanni Guglielmo [1 ]
Giulitti, Diego [1 ]
Pilozzi, Emanuela [2 ]
Ramacciato, Giovanni [1 ]
机构
[1] Univ Roma La Sapienza, Dept Gen Surg, St Andrea Hosp, Via Grottarossa 1035-1039, I-00189 Rome, Italy
[2] Univ Roma La Sapienza, Dept Pathol, St Andrea Hosp, Via Grottarossa 1035-1039, I-00189 Rome, Italy
关键词
Perineural invasion; Gastric cancer; Oncologic outcomes; Overall survival; Disease-free survival; IMPORTANT PROGNOSTIC-FACTOR; NODE-METASTASIS; CELLS PROMOTES; RECURRENCE; CARCINOMA; EXPRESSION; PATTERN;
D O I
10.1016/j.amjsurg.2016.05.022
中图分类号
R61 [外科手术学];
学科分类号
摘要
BACKGROUND: The aim of the present study was to evaluate the prognostic significance of perineural invasion (PNI) in locally advanced gastric cancer patients who underwent D2 gastrectomy and adjuvant chemotherapy. METHODS: The records of a series of 103 patients undergoing D2 gastrectomy with curative intent combined with adjuvant chemotherapy from January 2004 to December 2014 were retrospectively reviewed. RESULTS: PNI was positive in 47 (45.6%) specimens. The 1-, 3-, and 5-year overall survival rates were 81%, 55%, and 42%, respectively. The 1-, 3-, and 5-year disease-free survival (DFS) rates were 76%, 57%, and 49%, respectively. A multivariate analysis showed that age number of positive lymph nodes, T stage, and PNI were independently associated with overall survival. Regarding DFS, the multivariate analysis showed that only PNI was independently associated with DFS. CONCLUSIONS: PNI and T stage and positive lymph nodes are independent markers of poor prognosis in patients with gastric cancer. PNI should be incorporated in the postoperative staging system for planning follow-up after surgery and in our opinion to propose more aggressive postoperative therapies in PNI-positive patients. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:748 / 753
页数:6
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