Pretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinoma

被引：59
|
作者：
Jin, Ying [1 ]
Ye, Xiao [2 ]
He, Chunxiao [1 ]
Zhang, Beibei [1 ]
Zhang, Yiping [1 ]
机构：
[1] Zhejiang Canc Hosp, Dept Med Oncol, Hangzhou 310022, Zhejiang, Peoples R China
[2] Zhejiang Prov Peoples Hosp, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2015年 / 37卷 / 01期
关键词：
lymphocyte; metastatic nasopharyngeal carcinoma; neutrophil; neutrophil lymphocyte ratio; overall survival; PROGNOSTIC-FACTORS; UNDIFFERENTIATED CARCINOMA; PERIPHERAL NEUTROPHILS; DISTANT METASTASIS; POOR-PROGNOSIS; CANCER; EPIDEMIOLOGY; INFLAMMATION; TRAFFICKING; APOPTOSIS;
D O I：
10.1002/hed.23565
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundThe outcomes of patients with metastatic nasopharyngeal carcinoma (NPC) differ between individuals. The purpose of this study was to examine the impact of neutrophil-to-lymphocyte ratio (NLR) on survival in patients with metastatic NPC. MethodsA total of 229 patients with disseminated NPC were evaluated. The effects of pretreatment peripheral blood neutrophil, lymphocyte, and NLR on survival were examined using the proportional hazards regression model to estimate hazard ratio (HR). The relationship between short-term treatment efficacy and pretreatment NLR was analyzed using the chi-square test. ResultsThe pretreatment elevated neutrophil count (p=.020), percentage of neutrophil (p < .001), and NLR (p=.002) were statistically significantly associated with a poor prognosis. The cutoff value selected for NLR was 3.6. The median survival time was 15.3 months for the high-NLR group and was 23.5 months for the low-NLR group (p < .001). ConclusionNLR is a prognosticator in patients with metastatic NPC. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 69-75, 2015
引用
收藏
页码：69 / 75
页数：7
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