Importance of Nano Medicine and New Drug Therapies for Cancer

被引:25
作者
Abdolmaleki, Arash [1 ,2 ]
Asadi, Asadollah [3 ]
Gurushankar, Krishnamoorthy [4 ,5 ]
Shayan, Tahereh Karimi [3 ]
Sarvestani, Fatemeh Abedi [3 ]
机构
[1] Univ Mohaghegh Ardabili, Fac Adv Technol, Dept Engn Sci, Namin, Iran
[2] Sabalan Univ Adv Technol SUAT, Bio Sci & Biotechnol Res Ctr BBRC, Namin, Iran
[3] Univ Mohaghegh Ardabili, Fac Sci, Dept Biol, Ardebil, Iran
[4] South Ural State Univ, Higher Med & Biol Sch, Lab Computat Modeling Drugs, Chelyabinsk 454080, Russia
[5] Kalasalingam Acad Res & Educ, Dept Phys, Krishnankoil 626126, Tamil Nadu, India
关键词
Cancer; Drug; Nanomedicine; Drug delivery system; POLYMERIC NANOPARTICLES; COLORECTAL-CANCER; MESOPOROUS SILICA; ORAL DELIVERY; PH; RECEPTOR; MICROENVIRONMENT; SYSTEMS; SIRNA; TRANSFERRIN;
D O I
10.34172/apb.2021.052
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cancer is one of the deadly diseases leading to approximately 7.6 million deaths worldwide, with the mortality rate of 13%, and the number of deaths is expected to increase to 13.1 million within the next 10 years. In controlled drug delivery systems, the drug is transported to the desired location. Thus, the influence of drugs on vital tissues and undesirable side effects can be minimised. Additionally, drug delivery system protects the drug from rapid degradation or clearance and enhances drug concentration in target tissues, and therefore, minimise the required dose of drug. This modern form of therapy is particularly important when there is a discrepancy between the dose and concentration of a drug. Cell-specific targeting can be achieved by attaching drugs to individually designed carriers. Recent developments in nanotechnology have shown that nanoparticles (particles with diameter <100 nm in at least one dimension) have great potential as drug carriers. Because of their small size, these nanostructures exhibit unique physicochemical and biological properties that make them a favourable material for biomedical applications. Therefore, in this review, we aimed to describe the importance and types of nanomedicines and efficient ways in which new drug delivery systems for the treatment of cancer can be developed.
引用
收藏
页码:450 / 457
页数:8
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