N-sulfinyl β-amino Weinreb amides:: Synthesis of enantiopure β-amino carbonyl compounds.: Asymmetric synthesis of (+)-sedridine and (-)-allosedridine

被引：83

作者：

Davis, FA ^{[1
]}

Prasad, KR ^{[1
]}

Nolt, MB ^{[1
]}

Wu, YZ ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 06期

关键词：

D O I：

10.1021/ol034119z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Sulfinyl beta-amino Weinreb amides are prepared by condensation of sulfinimines with the potassium enolate of N-methoxy-N-methylacetamide. These new chiral building blocks are useful for the asymmetric synthesis of beta-amino carbonyl compounds, as illustrated here by the concise enantioselective syntheses of sedum alkaloids (+)-sedridine and (-)-allosedridine.

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页码：925 / 927

页数：3

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