A Review of Clinical Trials in Spinal Cord Injury Including Biomarkers

被引：41

作者：

Badhiwala, Jetan H. ^{[1
]}

Wilson, Jefferson R. ^{[1
]}

Kwon, Brian K. ^{[2
]}

Casha, Steven ^{[3
]}

Fehlings, Michael G. ^{[1
]}

机构：

[1] Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada

[2] Univ British Columbia, Vancouver Spine Surg Inst, Dept Orthoped, Vancouver, BC, Canada

[3] Univ Calgary, Sect Neurosurg, Dept Clin Neurosci, Calgary, AB, Canada

来源：

JOURNAL OF NEUROTRAUMA | 2018年 / 35卷 / 16期

关键词：

clinical trials; neuroprotection; regeneration; spinal cord injury; trauma; THYROTROPIN-RELEASING-HORMONE; CEREBROSPINAL-FLUID; ANTI-NOGO; NEUROLOGICAL RECOVERY; FUNCTIONAL RECOVERY; TIRILAZAD MESYLATE; SECONDARY INJURY; POLYMER SCAFFOLD; WALKING INDEX; BLOOD-FLOW;

D O I：

10.1089/neu.2018.5935

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Acute traumatic spinal cord injury (SCI) entered the arena of prospective, randomized clinical trials almost 40 years ago, with the undertaking of the National Acute Spinal Cord Study (NASCIS) I trial. Since then, a number of clinical trials have been conducted in the field, spurred by the devastating physical, social, and economic consequences of acute SCI for patients, families, and society at large. Many of these have been controversial and attracted criticism. The current review provides a critical summary of select past and current clinical trials in SCI, focusing in particular on the findings of prospective, randomized controlled trials, the challenges and barriers encountered, and the valuable lessons learned that can be applied to future trials.

引用

页码：1906 / 1917

页数：12

共 95 条

[21] Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system [J].

Dubreuil, CI ;

Winton, MJ ;

McKerracher, L .

JOURNAL OF CELL BIOLOGY, 2003, 162 (02) :233-243

[22] THYROTROPIN-RELEASING-HORMONE IN EXPERIMENTAL SPINAL-INJURY - DOSE-RESPONSE AND LATE TREATMENT [J].

FADEN, AI ;

JACOBS, TP ;

SMITH, MT .

NEUROLOGY, 1984, 34 (10) :1280-1284

[23] Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial [J].

Fehlings, M. G. ;

Nakashima, H. ;

Nagoshi, N. ;

Chow, D. S. L. ;

Grossman, R. G. ;

Kopjar, B. .

SPINAL CORD, 2016, 54 (01) :8-15

[24] THE EFFECT OF NIMODIPINE AND DEXTRAN ON AXONAL FUNCTION AND BLOOD-FLOW FOLLOWING EXPERIMENTAL SPINAL-CORD INJURY [J].

FEHLINGS, MG ;

TATOR, CH ;

LINDEN, RD .

JOURNAL OF NEUROSURGERY, 1989, 71 (03) :403-416

[25]

Fehlings Michael G, 2014, Neurosurgery, V61 Suppl 1, P36, DOI 10.1227/NEU.0000000000000412

[26] Early versus Delayed Decompression for Traumatic Cervical Spinal Cord Injury: Results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS) [J].

Fehlings, Michael G. ;

Vaccaro, Alexander ;

Wilson, Jefferson R. ;

Singh, Anoushka ;

Cadotte, David W. ;

Harrop, James S. ;

Aarabi, Bizhan ;

Shaffrey, Christopher ;

Dvorak, Marcel ;

Fisher, Charles ;

Arnold, Paul ;

Massicotte, Eric M. ;

Lewis, Stephen ;

Rampersaud, Raja .

PLOS ONE, 2012, 7 (02)

[27] Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury [J].

Fehlings, Michael G. ;

Theodore, Nicholas ;

Harrop, James ;

Maurais, Gilles ;

Kuntz, Charles ;

Shaffrey, Chris I. ;

Kwon, Brian K. ;

Chapman, Jens ;

Yee, Albert ;

Tighe, Allyson ;

McKerracher, Lisa .

JOURNAL OF NEUROTRAUMA, 2011, 28 (05) :787-796

[28] Regenerating corticospinal fibers in the Marmoset (Callitrix jacchus) after spinal cord lesion and treatment with the anti-Nogo-A antibody IN-1 [J].

Fouad, K ;

Klusman, I ;

Schwab, ME .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 20 (09) :2479-2482

[29]

Frankel H L, 1969, Paraplegia, V7, P179

[30] Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey [J].

Freund, Patrick ;

Wannier, Thierry ;

Schmidlin, Eric ;

Bloch, Jocelyne ;

Mir, Anis ;

Schwab, Martin E. ;

Rouiller, Eric M. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2007, 502 (04) :644-659

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