A Review of Clinical Trials in Spinal Cord Injury Including Biomarkers

被引：41
作者：
Badhiwala, Jetan H. [1 ]
Wilson, Jefferson R. [1 ]
Kwon, Brian K. [2 ]
Casha, Steven [3 ]
Fehlings, Michael G. [1 ]
机构：
[1] Univ Toronto, Div Neurosurg, Dept Surg, Toronto, ON, Canada
[2] Univ British Columbia, Vancouver Spine Surg Inst, Dept Orthoped, Vancouver, BC, Canada
[3] Univ Calgary, Sect Neurosurg, Dept Clin Neurosci, Calgary, AB, Canada
来源：
JOURNAL OF NEUROTRAUMA | 2018年 / 35卷 / 16期
关键词：
clinical trials; neuroprotection; regeneration; spinal cord injury; trauma; THYROTROPIN-RELEASING-HORMONE; CEREBROSPINAL-FLUID; ANTI-NOGO; NEUROLOGICAL RECOVERY; FUNCTIONAL RECOVERY; TIRILAZAD MESYLATE; SECONDARY INJURY; POLYMER SCAFFOLD; WALKING INDEX; BLOOD-FLOW;
D O I：
10.1089/neu.2018.5935
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Acute traumatic spinal cord injury (SCI) entered the arena of prospective, randomized clinical trials almost 40 years ago, with the undertaking of the National Acute Spinal Cord Study (NASCIS) I trial. Since then, a number of clinical trials have been conducted in the field, spurred by the devastating physical, social, and economic consequences of acute SCI for patients, families, and society at large. Many of these have been controversial and attracted criticism. The current review provides a critical summary of select past and current clinical trials in SCI, focusing in particular on the findings of prospective, randomized controlled trials, the challenges and barriers encountered, and the valuable lessons learned that can be applied to future trials.
引用
收藏
页码：1906 / 1917
页数：12
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