Clinical usefulness of postoperative C-reactive protein/albumin ratio in pancreatic ductal adenocarcinoma

被引：39

作者：

Arima, Kota ^{[1
]}

Yamashita, Yo-ichi ^{[1
]}

Hashimoto, Daisuke ^{[1
]}

Nakagawa, Shigeki ^{[1
]}

Umezaki, Naoki ^{[1
]}

Yamao, Takanobu ^{[1
]}

Tsukamoto, Masayo ^{[1
]}

Kitano, Yuki ^{[1
]}

Yamamura, Kensuke ^{[1
]}

Miyata, Tatsunori ^{[1
]}

Okabe, Hirohisa ^{[1
]}

Ishimoto, Takatsugu ^{[1
]}

Imai, Katsunori ^{[1
]}

Chikamoto, Akira ^{[1
]}

Baba, Hideo ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol Surg, Chuo Ku, 1-1-1 Honjo, Kumamoto 8608556, Japan

来源：

AMERICAN JOURNAL OF SURGERY | 2018年 / 216卷 / 01期

基金：

日本学术振兴会;

关键词：

CRP/Albumin ratio; Pancreatic ductal adenocarcinoma; Postoperative marker; TO-LYMPHOCYTE RATIO; LONG-TERM SURVIVAL; STRESS E-PASS; PHYSIOLOGICAL ABILITY; PROGNOSTIC SCORE; CANCER-PATIENTS; COMPLICATIONS; SURGERY; SYSTEM; INFLAMMATION;

D O I：

10.1016/j.amjsurg.2017.08.016

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Patients' prognoses have been predicted by the preoperative inflammation-based score, but predicting a patient's risk for operative load remains challenging. This study investigates the usefulness of the postoperative C-reactive protein/albumin (CRP/Alb) ratio in patients with pancreatic ductal adenocarcinoma (PDAC). Methods: This study retrospectively assessed 142 patients who underwent pancreatic resection for PDAC between 2004 and 2014. The time at which perioperative CRP/Alb ratio most influences the prognosis was identified, and the correlations among the perioperative CRP/Alb ratio, clinicopathological factors, and patient outcomes were investigated. Results: Among the perioperative CRP/Alb ratios, only a high CRP/Alb ratio at postoperative day 14 (POD14) was significantly associated with shorter overall survival (OS) and relapse-free survival (RFS). High CRP/Alb ratio at POD 14 was related to high BMI, large amount of intraoperative bleeding, and the presence of complications. Finally, high CRP/Alb at POD14 was an independent prognostic factor of poor OS and RFS. Conclusions: The CRP/Alb ratio at POD14 is a useful predictive marker of surgical invasion, biological reaction, and prognosis in PDAC patients. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：111 / 115

页数：5

共 26 条

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