Ultrasonication of chitosan nanoparticle suspension: Influence on particle size

被引：100
作者：
Gokce, Yavuz [1 ]
Cengiz, Burcu [1 ]
Yildiz, Nuray [1 ]
Calimli, Ayla [1 ]
Aktas, Zeki [1 ]
机构：
[1] Ankara Univ, Dept Chem Engn, TR-06100 Ankara, Turkey
来源：
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2014年 / 462卷
关键词：
Chitosan nanoparticles; Freeze-drying; Ultrasonication; Ionic gelation; SODIUM TRIPOLYPHOSPHATE; DELIVERY-SYSTEM; DRUG-DELIVERY; GENE DELIVERY; STABILITY; POLYDISPERSITY; MONODISPERSE; BEHAVIOR; SORPTION; QUALITY;
D O I：
10.1016/j.colsurfa.2014.08.028
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Chitosan nanoparticles have been prepared using an ionic gelation method. The effects of freeze-drying, cryoprotectant (D-trehalose) utilisation and ultrasonication time on the mean particle size, size distribution and stability of nanoparticles were investigated. The size distribution results indicated that freeze-drying caused the particles to agglomerate. Addition of the cryoprotectant and ultrasonication led to a decrease in the particle size. However the sizes of the nanoparticles increased with increasing ultrasonication time. Transmission electron microscopy images revealed that spherical chitosan nanoparticles ranging from 3 to 12 nm were obtained by means of freeze-drying in the presence of cryoprotectant and ultrasonication. These results suggest that cryoprotectant utilisation and controlled ultrasonic treatment are effective for imparting nanoparticle stability. (C) 2014 Elsevier B.V. All rights reserved.
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收藏
页码：75 / 81
页数：7
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