Structurally Diverse α-Substituted Benzopyran Synthesis through a Practical Metal-Free C(sp3)-H Functionalization

被引：81

作者：

Chen, Wenfang ^{[1
]}

Xie, Zhiyu ^{[1
]}

Zheng, Hongbo ^{[1
]}

Lou, Hongxiang ^{[1
]}

Liu, Lei ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 22期

基金：

美国国家科学基金会;

关键词：

C-H BONDS; COUPLING REACTIONS; CHROMENE ACETALS; BENZYLIC ETHERS; TERTIARY-AMINES; ACID; ALKYLATION; OXIDATION; ARYLATION; ADJACENT;

D O I：

10.1021/ol503004a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A trityl ion-mediated practical C-H functionalization of a variety of benzopyrans with a wide range of nucleophiles (organoboranes and C-H molecules) at ambient temperature has been disclosed. The metal-free reaction has an excellent functional group tolerance and high chemoselectivity and displays a broad scope with respect to both benzopyran and nucleophile partners, efficiently affording a collection of benzopyrans bearing diverse skeletons and alpha-functionalities in one step.

引用

页码：5988 / 5991

页数：4

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