The Role of Vitamin D in the Immune System as a Pro-survival Molecule

被引：91

作者：

Chirumbolo, Salvatore ^{[1
]}

Bjorklund, Geir ^{[2
]}

Sboarina, Andrea ^{[3
]}

Vella, Antonio ^{[4
]}

机构：

[1] Univ Verona, Dept Neurol & Movement Sci, Str Le Grazie 9, I-37134 Verona, Italy

[2] Council Nutr & Environm Med, Mo I Rana, Norway

[3] Univ Verona, Dept Surg Dent Gynaecol & Paediat, Verona, Italy

[4] Univ Verona, Azienda Osped Univ Integrata, Dept Med, Verona, Italy

来源：

CLINICAL THERAPEUTICS | 2017年 / 39卷 / 05期

关键词：

vitamin D; mitochondria; cell survival; redox signaling; immunity; D-RECEPTOR GENE; ENDOPLASMIC-RETICULUM STRESS; SERUM 25-HYDROXYVITAMIN D; INHIBITS NEUTROPHIL RECRUITMENT; TOLL-LIKE RECEPTOR-2; REGULATORY T-CELLS; ACUTE LUNG INJURY; D DEFICIENCY; D SUPPLEMENTATION; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3;

D O I：

10.1016/j.clinthera.2017.03.021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: Vitamin D is a fascinating and attractive molecule that has gained particular attention in medicine in recent years. Its immunomodulatory and anti-inflammatory potential might resemble the activity of many nature-derived molecules (eg, flavonoids), but its role in biology was selected during a long evolutionary pathway to dampen the damaging effect of cell stress response and of the immune reaction. In this sense, this molecule can be considered an ancient hormone that serves, in its primary role, as a pro-survival agent. The goal of this review was to elucidate this topic. Methods: The article reviews current literature on the field, focusing on issues regarding the role of vitamin D in immunity. Findings: Vitamin D participates in the survival machinery used by the cell, and in particular it plays a major role in synchronizing calcium oscillatory signaling to allow cell autophagy or apoptosis during a stress response. (C) 2017 Elsevier HS Journals, Inc. All rights reserved.

引用

页码：894 / 916

页数：23

共 244 条

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