BRCA2 Mutation as a Possible Cause of Poor Response to 177Lu-PSMA Therapy

被引：10

作者：

Ahmadzadehfar, Hojjat ^{[1
]}

Gaertner, Florian ^{[1
]}

Lossin, Philipp S. ^{[2
]}

Schwarz, Bettina ^{[1
]}

Essler, Markus ^{[1
]}

机构：

[1] Univ Hosp Bonn, Dept Nucl Med, Sigmund Freud Str 25, D-53127 Bonn, Germany

[2] Urol Ctr Bonn Rhein Sieg, Bonn, Germany

来源：

CLINICAL NUCLEAR MEDICINE | 2018年 / 43卷 / 08期

关键词：

Lu-177-PSMA therapy; castration-resistant prostate cancer; BRCA2; mutation; PARP inhibitor; METASTATIC PROSTATE-CANCER; RADIOLIGAND THERAPY; LU-177-PSMA-617; OLAPARIB; CYCLES;

D O I：

10.1097/RLU.0000000000002141

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We present the case of a 66-year-old man with castration-resistant prostate cancer, with an increasing prostate-specific antigen level, and a progressive disease during Lu-177-PSMA radionuclide therapy. Because the patient had a BRCA2 mutation, poly-ADP ribose polymerase inhibitor therapy was started. The patient showed a dramatic subjective and biological response to this therapy with a progression-free survival of 5 months.

引用

页码：609 / 610

页数：2

共 9 条

[1] Radioligand therapy of metastatic prostate cancer using 177Lu-PSMA-617 after radiation exposure to 223Ra-dichloride [J].

Ahmadzadehfar, Hojjat ;

Zimbelmann, Stefanie ;

Yordanova, Anna ;

Fimmers, Rolf ;

Kuerpig, Stefan ;

Eppard, Elisabeth ;

Gaertner, Florian C. ;

Wei, Xiao ;

Hauser, Stefan ;

Essler, Markus .

ONCOTARGET, 2017, 8 (33) :55567-55574

[2] Overall survival and response pattern of castration-resistant metastatic prostate cancer to multiple cycles of radioligand therapy using [177Lu]Lu-PSMA-617 [J].

Ahmadzadehfar, Hojjat ;

Wegen, Simone ;

Yordanova, Anna ;

Fimmers, Rolf ;

Kuerpig, Stefan ;

Eppard, Elisabeth ;

Wei, Xiao ;

Schlenkhoff, Carl ;

Hauser, Stefan ;

Essler, Markus .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 (09) :1448-1454

[3] Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer [J].

Ahmadzadehfar, Hojjat ;

Eppard, Elisabeth ;

Kuerpig, Stefan ;

Fimmers, Rolf ;

Yordanova, Anna ;

Schlenkhoff, Carl Diedrich ;

Gaertner, Florian ;

Rogenhofer, Sebastian ;

Essler, Markus .

ONCOTARGET, 2016, 7 (11) :12477-12488

[4] Predictors of Response to Radioligand Therapy of Metastatic Castrate-Resistant Prostate Cancer with 177Lu-PSMA-617 [J].

Ferdinandus, Justin ;

Eppard, Elisabeth ;

Gaertner, Florian C. ;

Kuerpig, Stefan ;

Fimmers, Rolf ;

Yordanova, Anna ;

Hauser, Stefan ;

Feldmann, Georg ;

Essler, Markus ;

Ahmadzadehfar, Hojjat .

JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (02) :312-319

[5] A Novel Use of Olaparib for the Treatment of Metastatic Castration-Recurrent Prostate Cancer [J].

Martin, Grace A. ;

Chen, Adrienne H. ;

Parikh, Kinjal .

PHARMACOTHERAPY, 2017, 37 (11) :1406-1414

[6] DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer [J].

Mateo, J. ;

Carreira, S. ;

Sandhu, S. ;

Miranda, S. ;

Mossop, H. ;

Perez-Lopez, R. ;

Rodrigues, D. Nava ;

Robinson, D. ;

Omlin, A. ;

Tunariu, N. ;

Boysen, G. ;

Porta, N. ;

Flohr, P. ;

Gillman, A. ;

Figueiredo, I. ;

Paulding, C. ;

Seed, G. ;

Jain, S. ;

Ralph, C. ;

Protheroe, A. ;

Hussain, S. ;

Jones, R. ;

Elliott, T. ;

McGovern, U. ;

Bianchini, D. ;

Goodall, J. ;

Zafeiriou, Z. ;

Williamson, C. T. ;

Ferraldeschi, R. ;

Riisnaes, R. ;

Ebbs, B. ;

Fowler, G. ;

Roda, D. ;

Yuan, W. ;

Wu, Y. -M. ;

Cao, X. ;

Brough, R. ;

Pemberton, H. ;

A'Hern, R. ;

Swain, A. ;

Kunju, L. P. ;

Eeles, R. ;

Attard, G. ;

Lord, C. J. ;

Ashworth, A. ;

Rubin, M. A. ;

Knudsen, K. E. ;

Feng, F. Y. ;

Chinnaiyan, A. M. ;

Hall, E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (18) :1697-1708

[7] German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients [J].

Rahbar, Kambiz ;

Ahmadzadehfar, Hojjat ;

Kratochwil, Clemens ;

Haberkorn, Uwe ;

Schaefers, Michael ;

Essler, Markus ;

Baum, Richard P. ;

Kulkarni, Harshad R. ;

Schmidt, Matthias ;

Drzezga, Alexander ;

Bartenstein, Peter ;

Pfestroff, Andreas ;

Luster, Markus ;

Luetzen, Ulf ;

Marx, Marlies ;

Prasad, Vikas ;

Brenner, Winfried ;

Heinzel, Alexander ;

Mottaghy, Felix M. ;

Ruf, Juri ;

Meyer, Philipp Tobias ;

Heuschkel, Martin ;

Eveslage, Maria ;

Boegemann, Martin ;

Fendler, Wolfgang Peter ;

Krause, Bernd Joachim .

JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (01) :85-90

[8] Metastatic Prostate Cancer [J].

Sartor, Oliver ;

de Bono, Johann S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (07) :645-657

[9] The impact of repeated cycles of radioligand therapy using [177Lu] Lu-PSMA-617 on renal function in patients with hormone refractory metastatic prostate cancer [J].

Yordanova, Anna ;

Becker, Anja ;

Eppard, Elisabeth ;

Kuerpig, Stefan ;

Fisang, Christian ;

Feldmann, Georg ;

Essler, Markus ;

Ahmadzadehfar, Hojjat .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 (09) :1473-1479

← 1 →