Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium

被引：33

作者：

Geijsen, Anne J. M. R. ^{[1
]}

van Roekel, Eline H. ^{[2
]}

van Duijnhoven, Franzel J. B. ^{[1
]}

Achaintre, David ^{[3
]}

Bachleitner-Hofmann, Thomas ^{[4
]}

Baierl, Andreas ^{[5
]}

Bergmann, Michael M. ^{[4
]}

Boehm, Jurgen ^{[6
,7
]}

Bours, Martijn J. L. ^{[2
]}

Brenner, Hermann ^{[8
,9
,10
]}

Breukink, Stephanie O. ^{[11
]}

Brezina, Stefanie ^{[12
]}

Chang-Claude, Jenny ^{[13
]}

Herpel, Esther ^{[14
]}

de Wilt, Johannes H. W. ^{[15
]}

Gicquiau, Audrey ^{[3
]}

Gigic, Biljana ^{[16
]}

Gumpenberger, Tanja ^{[12
]}

Hansson, Bibi M. E. ^{[17
]}

Hoffmeister, Michael ^{[9
]}

Holowatyj, Andreana N. ^{[6
,7
]}

Karner-Hanusch, Judith ^{[4
]}

Keski-Rahkonen, Pekka ^{[3
]}

Keulen, Eric T. P. ^{[18
]}

Koole, Janna L. ^{[2
]}

Leeb, Gernot ^{[19
]}

Ose, Jennifer ^{[6
,7
]}

Schirmacher, Peter ^{[14
]}

Schneider, Martin A. ^{[16
]}

Schrotz-King, Petra ^{[8
]}

Stift, Anton ^{[4
]}

Ulvik, Arve ^{[20
]}

Vogelaar, F. Jeroen ^{[21
]}

Wesselink, Evertine ^{[1
]}

van Zutphen, Moniek ^{[1
]}

Gsur, Andrea ^{[12
]}

Habermann, Nina ^{[8
,22
]}

Kampman, Ellen ^{[1
]}

Scalbert, Augustin ^{[3
]}

Ueland, Per M. ^{[20
]}

Ulrich, Alexis B. ^{[16
]}

Ulrich, Cornelia M. ^{[6
,7
]}

Weijenberg, Matty P. ^{[2
]}

Kok, Dieuwertje E. ^{[1
]}

机构：

[1] Wageningen Univ & Res, Div Human Nutr & Hlth, POB 17, NL-6700 AA Wageningen, Netherlands

[2] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands

[3] Int Agcy Res Canc, Biomarkers Grp, Lyon, France

[4] Med Univ Vienna, Dept Surg, Vienna, Austria

[5] Univ Vienna, Dept Stat & Operat Res, Vienna, Austria

[6] Huntsman Canc Inst, Salt Lake City, UT USA

[7] Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA

[8] Natl Ctr Tumor Dis & German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany

[9] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[10] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[11] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Surg, Maastricht, Netherlands

[12] Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria

[13] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[14] Heidelberg Univ, Inst Pathol, Heidelberg, Germany

[15] Radboud Univ Nijmegen, Dept Surg, Div Surg Oncol & Gastrointestinal Surg, Med Ctr, Nijmegen, Netherlands

[16] Heidelberg Univ, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany

[17] Canisius Wilhelmina Hosp, Dept Surg, Nijmegen, Netherlands

[18] Zuyderland Med Ctr, Dept Internal Med & Gastroenterol, Sittard, Netherlands

[19] Hosp Oberpullendorf, Burgenland, Austria

[20] BEVITAL, Bergen, Norway

[21] VieCuri Med Ctr, Dept Surg, Venlo, Netherlands

[22] EMBL, Genome Biol, Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF CANCER | 2020年 / 146卷 / 12期

基金：

美国国家卫生研究院;

关键词：

colorectal cancer; disease stage; metabolomics; plasma metabolites; epidemiology; METABOLOMICS; VARIABILITY; SERUM;

D O I：

10.1002/ijc.32666

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer is the second most common cause of cancer-related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites in relation to disease stage to improve the understanding of metabolic pathways related to colorectal cancer progression. We investigated plasma concentrations of 130 metabolites among 744 Stages I-IV colorectal cancer patients from ongoing cohort studies. Plasma samples, collected at diagnosis, were analyzed with liquid chromatography-mass spectrometry using the Biocrates AbsoluteIDQ (TM) p180 kit. We assessed associations between metabolite concentrations and stage using multinomial and multivariable logistic regression models. Analyses were adjusted for potential confounders as well as multiple testing using false discovery rate (FDR) correction. Patients presented with 23, 28, 39 and 10% of Stages I-IV disease, respectively. Concentrations of sphingomyelin C26:0 were lower in Stage III patients compared to Stage I patients (p(FDR) < 0.05). Concentrations of sphingomyelin C18:0 and phosphatidylcholine (diacyl) C32:0 were statistically significantly higher, while citrulline, histidine, phosphatidylcholine (diacyl) C34:4, phosphatidylcholine (acyl-alkyl) C40:1 and lysophosphatidylcholines (acyl) C16:0 and C17:0 concentrations were lower in Stage IV compared to Stage I patients (p(FDR) < 0.05). Our results suggest that metabolic pathways involving among others citrulline and histidine, implicated previously in colorectal cancer development, may also be linked to colorectal cancer progression.

引用

页码：3256 / 3266

页数：11

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