Mitochondrial dynamics in neurodegenerative diseases

被引：0

作者：

Alarcon-Aguilar, Adriana ^{[1
]}

Maycotte-Gonzalez, Paola ^{[2
]}

Cortes-Hernandez, Paulina ^{[2
]}

Edith Lopez-Diazguerrero, Norma ^{[1
]}

Konigsberg, Mina ^{[1
]}

机构：

[1] Univ Autonoma Metropolitana, Dept Hlth Sci, Ciudad De Mexico, Mexico

[2] Ctr Invest Biomed Oriente, Inst Mexicano Seguro Social, Puebla, Mexico

来源：

GACETA MEDICA DE MEXICO | 2019年 / 155卷 / 03期

关键词：

Mitochondria; Neurodegenerative diseases; Oxidative stress; Neurons; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; PROTEIN DRP1; MOUSE MODEL; DYSFUNCTION; FISSION; BIOGENESIS; MITOPHAGY; FUSION; MECHANISMS;

D O I：

10.24875/GMM.M19000270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurodegenerative diseases are a group of heterogeneous diseases characterized by a gradual, progressive and selective decrease in nervous system functions. The etiology of these pathologies remains unknown; however, mitochondrial function has been proposed as a common factor that could be involved in the establishment of these diseases, owing to the high energy requirement neurons have in order to carry out their physiological functions. Mitochondria are extremely dynamic organelles that can change their morphology and function in response to different physiological stimuli and, for this reason, mitochondrial dynamics have started being studied as one of cell survival main regulators. This event comprises different processes, such as the generation of new mitochondria and their elimination when they are no longer functional, as well as mitochondrial fusion and fission processes and the traffic of these organelles within the cellular environment. All these processes are highly regulated, and their main purpose is optimal functionality of mitochondria and cellular homeostasis.

引用

页码：254 / 260

页数：7

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