The interplay of post-translational modification and gene therapy

被引：4
作者：
Osamor, Victor Chukwudi [1 ,2 ,3 ]
Chinedu, Shalom N. [1 ,3 ,4 ]
Azuh, Dominic E. [1 ,3 ,5 ]
Iweala, Emeka Joshua [3 ,4 ]
Ogunlana, Olubanke Olujoke [3 ,4 ]
机构：
[1] Covenant Univ, Covenant Univ Bioinformat Res CUBRe Unit, CST, Dept Comp & Informat Sci, Ota, Ogun State, Nigeria
[2] Univ Warsaw, Fac Math Informat & Mech, Inst Informat Computat Biol & Bioinformat, Warsaw, Poland
[3] Covenant Univ, Covenant Univ Publ Hlth & Well Being Res Grp CUPH, Ota, Ogun State, Nigeria
[4] Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Biochem & Mol Biol Unit,Canaan Land, Ota, Ogun State, Nigeria
[5] Covenant Univ, Dept Econ & Dev Studies, Ota, Ogun State, Nigeria
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2016年 / 10卷
关键词：
post-translational modification; gene therapy; epigenetics; histone; methylation; NUCLEOSOME CORE PARTICLE; INNATE IMMUNE-RESPONSES; FACTOR-IX; PREEXISTING IMMUNITY; LYSINE SUCCINYLATION; PROTEIN MODIFICATION; SKELETAL-MUSCLE; HISTONE H3; VECTOR; COMPLEX;
D O I：
10.2147/DDDT.S80496
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on whether histone marks are read, added, or removed, respectively, from a specific amino acid. Transcription is controlled by dynamic epigenetic marks with serious health implications in certain complex diseases, whose understanding may be useful in gene therapy. This work highlights traditional and current advances in post-translational modifications with relevance to gene therapy delivery. We report that enhanced understanding of epigenetic machinery provides clues to functional implication of certain genes/gene products and may facilitate transition toward revision of our clinical treatment procedure with effective fortification of gene therapy delivery.
引用
收藏
页码：861 / 871
页数：11
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