Chiral 1,3,6-trisubstituted 2,4-dioxohexahydropyrimidines:: a convenient stereoselective synthesis from aspartic acid derivatives

被引：10
|
作者：
Patino-Molina, Rosario
Cubero-Lajo, Ivan
Jesus Perez de Vega, M.
Garcia-Lopez, M. Teresa
Gonzalez-Muniz, Rosario
机构：
[1] Univ Valladolid, Escuela Tecn Super Ingn Ind, E-47071 Valladolid, Spain
[2] CSIC, Inst Quim Med, E-28006 Madrid, Spain
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 20期
关键词：
D O I：
10.1016/j.tetlet.2007.03.066
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral 1,3,6-trisubstituted 2,4-dioxohexahydropyrimidines were easily synthesized by reaction of homoaspartic acid derivatives with isocyanates, followed by cyclization of the resulting urea, and alkylation at N1 position. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3613 / 3616
页数：4
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