Chemo- and Regioselective Magnesium-Catalyzed ortho-Alkenylation of Anilines

被引：32

作者：

Chatupheeraphat, Adisak ^{[1
]}

Rueping, Magnus ^{[1
,2
]}

Magre, Marc ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] KAUST, KCC, Thuwal 239556900, Saudi Arabia

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 22期

关键词：

C-H FUNCTIONALIZATION; ORTHO-ARYLATION; ANILIDES; ACTIVATION; ALKYNES; HYDROAMINATION; ACIDS;

D O I：

10.1021/acs.orglett.9b03526

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient catalytic system for a chemo- and regioselective ortho-alkenylation of anilines is presented. The new magnesium-catalyzed reaction allows the use of a wide range of alkynes and anilines with different electronic and steric properties and provides free as well as protected anilines with excellent yields.

引用

页码：9153 / 9157

页数：5

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