Autophagy: A novel mechanism of chemoresistance in cancers

被引：150

作者：

Li, Xinyu ^{[1
]}

Zhou, Yong ^{[1
]}

Li, Yongshuang ^{[1
]}

Yang, Liang ^{[1
]}

Ma, Yingbo ^{[1
]}

Peng, Xueqiang ^{[1
]}

Yang, Shuo ^{[1
]}

Liu, Jingang ^{[1
]}

Li, Hangyu ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shenyang 110000, Liaoning, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 119卷

基金：

中国国家自然科学基金;

关键词：

Autophagy; ATG; Drug resistance; Drug therapy; LONG NONCODING RNA; INTERACTING PROTEIN P62; CELL LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; SELECTIVE AUTOPHAGY; BECLIN; ATG12-ATG5; CONJUGATE; SORAFENIB RESISTANCE; TARGETING AUTOPHAGY; ARSENIC TRIOXIDE;

D O I：

10.1016/j.biopha.2019.109415

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The success of targeted drug therapy for cancer patients has attracted extensive attention from academia and society. However, the rapid development of acquired drug resistance is becoming a major challenge. Autophagy, as an essential homeostatic and catabolic process, is crucial for the degradation or recycling of proteins and cellular components. Autophagy has a crucial role in several cellular functions and its dysregulation is associated with tumorigenesis, tumor-stroma interactions, and resistance to cancer therapy. A growing body of evidence shows that in multiple types of cancer, autophagy is also a key regulator in the tumor microenvironment and the cellular drug response. However, our understanding of the process of autophagy remains incompletely. In this review, we identify the role of autophagy and describe recent advances in the identification of the mechanism by which autophagy is implicated in drug resistance, with a focus on the mode of action, and validation as potential therapeutics.

引用

页数：11

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