Computational Pathology A Path Ahead

被引:98
作者
Louis, David N. [1 ,2 ]
Feldman, Michael [3 ]
Carter, Alexis B. [4 ]
Dighe, Anand S. [1 ,2 ]
Pfeifer, John D. [5 ]
Bry, Lynn [2 ,6 ]
Almeida, Jonas S. [7 ]
Saltz, Joel [7 ]
Braun, Jonathan [8 ]
Tomaszewski, John E. [9 ]
Gilbertson, John R. [1 ,2 ]
Sinard, John H. [10 ]
Gerber, Georg K. [2 ,6 ]
Galli, Stephen J. [11 ]
Golden, Jeffrey A. [2 ,6 ]
Becich, Michael J. [12 ]
机构
[1] Massachusetts Gen Hosp, James Homer Wright Pathol Labs, WRN2,55 Fruit St, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
[4] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[5] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA
[6] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA
[7] SUNY Stony Brook, Dept Biomed Informat, Stony Brook, NY 11794 USA
[8] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[9] SUNY Buffalo, Dept Pathol & Anat Sci, Buffalo, NY 14260 USA
[10] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA
[11] Stanford Univ, Dept Pathol & Lab Med, Palo Alto, CA 94304 USA
[12] Univ Pittsburgh, Dept Biomed Informat, Pittsburgh, PA USA
关键词
SOMATIC MUTATIONS; DATABASE;
D O I
10.5858/arpa.2015-0093-SA
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Context.-We define the scope and needs within the new discipline of computational pathology, a discipline critical to the future of both the practice of pathology and, more broadly, medical practice in general. Objective.-To define the scope and needs of computational pathology. Data Sources.-A meeting was convened in Boston, Massachusetts, in July 2014 prior to the annual Association of Pathology Chairs meeting, and it was attended by a variety of pathologists, including individuals highly invested in pathology informatics as well as chairs of pathology departments. Conclusions.-The meeting made recommendations to promote computational pathology, including clearly defining the field and articulating its value propositions; asserting that the value propositions for health care systems must include means to incorporate robust computational approaches to implement data-driven methods that aid in guiding individual and population health care; leveraging computational pathology as a center for data interpretation in modern health care systems; stating that realizing the value proposition will require working with institutional administrations, other departments, and pathology colleagues; declaring that a robust pipeline should be fostered that trains and develops future computational pathologists, for those with both pathology and non-pathology backgrounds; and deciding that computational pathology should serve as a hub for data-related research in health care systems. The dissemination of these recommendations to pathology and bioinformatics departments should help facilitate the development of computational pathology.
引用
收藏
页码:41 / 50
页数:10
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