N-acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD

被引:161
作者
De Bellis, MD
Keshavan, MS
Spencer, S
Hall, J
机构
[1] Western Psychiat Inst & Clin, Dev Traumatol Neuroimaging Lab, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA
关键词
D O I
10.1176/appi.ajp.157.7.1175
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Anterior cingulate dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The authors hypothesized that integrity of the anterior cingulate may be affected in childhood PTSD. Method: Single voxel proton magnetic resonance spectroscopy (proton MRS) was used to measure the relative concentration of N-acetylaspartate and creatine, a marker of neural integrity, in the anterior cingulate of 11 children and adolescents who met DSM-IV criteria for PTSD secondary to maltreatment and 11 healthy matched comparison subjects. Results: The ratio of N-acetylaspartate to creatine was significantly lower in the maltreated subjects with PTSD than in the comparison subjects. Conclusions: The lower N-acetylaspartate/creatine ratio in subjects with PTSD suggests that anterior cingulate neuronal metabolism may be altered in childhood PTSD.
引用
收藏
页码:1175 / 1177
页数:3
相关论文
共 18 条
[1]  
[Anonymous], MR SPECTROSCOPY CLIN
[2]  
[Anonymous], CHILD ADOLESCENT PSY, DOI 10.1016/S1056-4993(18)30463-2
[3]  
Bremner JD, 1999, AM J PSYCHIAT, V156, P1787
[4]   Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study [J].
Bremner, JD ;
Staib, LH ;
Kaloupek, D ;
Southwick, SM ;
Soufer, R ;
Charney, DS .
BIOLOGICAL PSYCHIATRY, 1999, 45 (07) :806-816
[5]   Developmental traumatology Part I: Biological stress systems [J].
De Bellis, MD ;
Baum, AS ;
Birmaher, B ;
Keshavan, MS ;
Eccard, CH ;
Boring, AM ;
Jenkins, FJ ;
Ryan, ND .
BIOLOGICAL PSYCHIATRY, 1999, 45 (10) :1259-1270
[6]   Developmental traumatology Part II: Brain development [J].
De Bellis, MD ;
Keshavan, MS ;
Clark, DB ;
Casey, BJ ;
Giedd, JN ;
Boring, AM ;
Frustaci, K ;
Ryan, ND .
BIOLOGICAL PSYCHIATRY, 1999, 45 (10) :1271-1284
[7]  
DEBELLIS MD, 1997, HDB PREVENTION TREAT, P455
[8]  
DENCKLA MB, 1985, PSYCHOPHARMACOL BULL, V21, P773
[9]   Localized proton magnetic resonance spectroscopy of cerebral metabolites [J].
Frahm, J ;
Hanefeld, F .
NEUROPEDIATRICS, 1996, 27 (02) :64-69
[10]  
Hamner M B, 1999, Depress Anxiety, V9, P1