PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability

被引：64
作者：
Singh, Tanveer [1 ,2 ]
Mishra, Awanish [1 ,3 ]
Goel, Rajesh Kumar [1 ]
机构：
[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India
[2] Texas A&M Univ, Hlth Sci Ctr, Dept Neurosci & Expt Therapeut, Coll Med, Bryan, TX 77807 USA
[3] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Kamrup 781101, Assam, India
来源：
METABOLIC BRAIN DISEASE | 2021年 / 36卷 / 07期
关键词：
Pentylenetetrazole; Kindling; Refractory epilepsy; Epileptogenesis; Depression; Cognitive impairment; MEMORY DEFICIT; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; MOUSE MODEL; BEHAVIORAL COMORBIDITIES; ANTIEPILEPTIC DRUGS; STATUS EPILEPTICUS; INDUCED SEIZURES; PERMANENT CHANGE; FICUS-RELIGIOSA;
D O I：
10.1007/s11011-021-00823-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is also a simple and well accepted model of chronic epilepsy. PTZ kindling has been explored for studying epileptogenesis, epilepsy-associated comorbidities, and refractory epilepsy. This review summarizes the potential of PTZ kindling in mice and its modifications for its face, construct, and predictive validity to screen antiepileptogenic drugs, combined or add on novel and safe therapies for treatment of epilepsy-associated depression and cognitive impairment as well as effective interventions for pharmacoresistant epilepsy.
引用
收藏
页码：1573 / 1590
页数：18
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