PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability

被引：61

作者：

Singh, Tanveer ^{[1
,2
]}

Mishra, Awanish ^{[1
,3
]}

Goel, Rajesh Kumar ^{[1
]}

机构：

[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

[2] Texas A&M Univ, Hlth Sci Ctr, Dept Neurosci & Expt Therapeut, Coll Med, Bryan, TX 77807 USA

[3] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Kamrup 781101, Assam, India

来源：

METABOLIC BRAIN DISEASE | 2021年 / 36卷 / 07期

关键词：

Pentylenetetrazole; Kindling; Refractory epilepsy; Epileptogenesis; Depression; Cognitive impairment; MEMORY DEFICIT; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; MOUSE MODEL; BEHAVIORAL COMORBIDITIES; ANTIEPILEPTIC DRUGS; STATUS EPILEPTICUS; INDUCED SEIZURES; PERMANENT CHANGE; FICUS-RELIGIOSA;

D O I：

10.1007/s11011-021-00823-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is also a simple and well accepted model of chronic epilepsy. PTZ kindling has been explored for studying epileptogenesis, epilepsy-associated comorbidities, and refractory epilepsy. This review summarizes the potential of PTZ kindling in mice and its modifications for its face, construct, and predictive validity to screen antiepileptogenic drugs, combined or add on novel and safe therapies for treatment of epilepsy-associated depression and cognitive impairment as well as effective interventions for pharmacoresistant epilepsy.

引用

页码：1573 / 1590

页数：18

共 26 条

[1] PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability
Tanveer Singh
Awanish Mishra
Rajesh Kumar Goel
Metabolic Brain Disease, 2021, 36 : 1573 - 1590
[2] Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice
Koshal, Prashant
Kumar, Puneet
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2016, 415 (1-2) : 77 - 87
[3] Pharmacology of epileptogenesis and related comorbidities in the WAG/Rij rat model of genetic absence epilepsy
Russo, Emilio
Citraro, Rita
JOURNAL OF NEUROSCIENCE METHODS, 2018, 310 : 54 - 62
[4] Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy
Tawfik, Karim M.
Moustafa, Yasser M.
El-Azab, Mona F.
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 833 : 131 - 144
[5] Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice
Prashant Koshal
Puneet Kumar
Molecular and Cellular Biochemistry, 2016, 415 : 77 - 87
[6] Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model
Karabulut, Sebahattin
Filiz, Ahmet Kemal
Akkaya, Recep
NEUROLOGICAL RESEARCH, 2022, 44 (10) : 902 - 909
[7] Downregulatory effect of miR-342-3p on epileptogenesis in the PTZ-kindling model
Pala, Mukaddes
Meral, Ismail
Acikgoz, Nilgun Pala
Yilmaz, Senay Gorucu
Okur, Semra Karaca
Acar, Seyma
Polat, Yalcin
Akbas, Fahri
MOLECULAR BIOLOGY REPORTS, 2022, 49 (12) : 11997 - 12006
[8] Downregulatory effect of miR-342-3p on epileptogenesis in the PTZ-kindling model
Mukaddes Pala
Ismail Meral
Nilgun Pala Acikgoz
Senay Gorucu Yilmaz
Semra Karaca Okur
Seyma Acar
Yalcin Polat
Fahri Akbas
Molecular Biology Reports, 2022, 49 : 11997 - 12006
[9] Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities in mice by suppression of ROS/RNS
Jaiswal, Gagandeep
Kumar, Puneet
BEHAVIOURAL BRAIN RESEARCH, 2022, 419
[10] Role of DNA Methylation and Adenosine in Ketogenic Diet for Pharmacoresistant Epilepsy: Focus on Epileptogenesis and Associated Comorbidities
Chen, Fan
He, Xinghui
Luan, Guoming
Li, Tianfu
FRONTIERS IN NEUROLOGY, 2019, 10

← 1 2 3 →