Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells

被引：12
|
作者：
Zhou, Zhengquan [1 ]
Xie, Xian [1 ]
Yi, Qikun [1 ]
Yin, Wencui [2 ]
Kadi, Adnan A. [2 ]
Li, Jinbo [1 ]
Zhang, Yan [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China
[2] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh, Saudi Arabia
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 33期
基金：
中国国家自然科学基金;
关键词：
SUPRAMOLECULAR HYDROGELS; SMALL MOLECULES; DRUG; CHEMISTRY; FATE;
D O I：
10.1039/c7ob01548h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Using a short peptide precursor modified by the biaryltetrazole with intramolecular photo-click reactivity, we realized the photo-regulation of the pericellular nanofibers formed by the enzyme-instructed self-assembly on the cell membrane. Upon light irradiation, the fluorescence of nanofibers could be turned on to monitor both enzyme-instructed self-assembly and photoinduced disassembly processes. Moreover, the cell fate could be controlled through the photo-regulation.
引用
收藏
页码：6892 / 6895
页数：4
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