Quantitative positron emission tomography in brain research

被引：25

作者：

Heurling, Kerstin ^{[1
,2
,3
]}

Leuzy, Antoine ^{[4
]}

Jonasson, My ^{[3
,5
]}

Frick, Andreas ^{[6
,7
]}

Zimmer, Eduardo R. ^{[8
,9
]}

Nordberg, Agneta ^{[4
,10
]}

Lubberink, Mark ^{[3
,5
]}

机构：

[1] Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden

[2] Univ Gothenburg, Dept Psychiat & Neurochem, Gothenburg, Sweden

[3] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden

[4] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden

[5] Uppsala Univ Hosp, Med Phys, Uppsala, Sweden

[6] Uppsala Univ, Dept Psychol, Uppsala, Sweden

[7] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[8] Univ Fed Rio Grande do Sul, Dept Biochem, Porto Alegre, RS, Brazil

[9] Pontificia Univ Catolica Rio Grande do Sul, Brain Inst Rio Grande Sul Brains, Porto Alegre, RS, Brazil

[10] Karolinska Univ, Univ Hosp, Dept Geriatr Med, Stockholm, Sweden

来源：

BRAIN RESEARCH | 2017年 / 1670卷

关键词：

Brain; Diagnostics; Imaging biomarkers; Molecular imaging; Positron emission tomography; P-GLYCOPROTEIN FUNCTION; DOPAMINE-D-2 RECEPTOR OCCUPANCY; REFERENCE TISSUE MODEL; CEREBRAL-BLOOD-FLOW; IN-VIVO; ALZHEIMERS-DISEASE; PET TRACER; TAU PET; DIFFERENTIAL-DIAGNOSIS; SEROTONIN SYNTHESIS;

D O I：

10.1016/j.brainres.2017.06.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The application of positron emission tomography (PET) in brain research has increased substantially during the past 20 years, and is still growing. PET provides a unique insight into physiological and pathological processes in vivo. In this article we introduce the fundamentals of PET, and the methods available for acquiring quantitative estimates of the parameters of interest. A short introduction to different areas of application is also given, including basic research of brain function and in neurology, psychiatry, drug receptor occupancy studies, and its application in diagnostics of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Our aim is to inform the unfamiliar reader of the underlying basics and potential applications of PET, hoping to inspire the reader into considering how the technique could be of benefit for his or her own research. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：220 / 234

页数：15

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