Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

被引：420

作者：

Foster, Kathryn G. ^{[1
]}

Fingar, Diane C. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 19期

基金：

美国国家卫生研究院;

关键词：

RICH AKT SUBSTRATE; P70; S6; KINASE; 40 KDA PRAS40; PROTEIN-KINASE; AMINO-ACIDS; MOTIF PHOSPHORYLATION; TSC1-TSC2; COMPLEX; CYCLE PROGRESSION; RAG GTPASES; TOS MOTIF;

D O I：

10.1074/jbc.R109.094003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2. Differing sensitivities to the mTOR inhibitor rapamycin, unique partner proteins, distinct substrates, and unique cellular functions distinguish the complexes. Here, we review recent progress in our understanding of the regulation and function of mTOR signaling networks in cellular physiology.

引用

页码：14071 / 14077

页数：7

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