Successful anti-CD19 CAR T-cell therapy in HIV-infected patients with refractory high-grade B-cell lymphoma

被引：53

作者：

Abramson, Jeremy S. ^{[1
]}

Irwin, Kelly E. ^{[2
]}

Frigault, Matthew J. ^{[1
]}

Dietrich, Jorg ^{[3
]}

McGree, Brianne ^{[1
]}

Jordan, Justin T. ^{[3
]}

Yee, Andrew J. ^{[1
]}

Chen, Yi-Bin ^{[1
]}

Raje, Noopur S. ^{[1
]}

Barnes, Jeffrey A. ^{[1
]}

Davis, Benjamin ^{[4
]}

机构：

[1] Massachusetts Gen Hosp, Partment Med, Div Hematol Oncol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Psychiat, Div Psychiat Oncol, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Neurol, Div Neurooncol, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Med, Div Infect Dis, Boston, MA 02114 USA

来源：

CANCER | 2019年 / 125卷 / 21期

关键词：

HOMOLOGY;

D O I：

10.1002/cncr.32411

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HIV-positive patients have been excluded from clinical trials evaluating chimeric antigen receptor (CAR) T-cell therapies. Herein, the authors report on 2 patients with HIV/AIDS-associated, chemotherapy-refractory, aggressive B-cell lymphomas who were treated successfully with the anti-CD19 CAR T-cell product axicabtagene ciloleucel.

引用

页码：3692 / 3698

页数：7

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