Synthesis of cis-4-trifluoromethyl- and cis-4-difluoromethyl-L-pyroglutamic acids

被引：32
作者：
Qiu, XL
Qing, FL
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[2] Donghua Univ, Coll Chem & Chem Engn, Shanghai 200051, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 09期
关键词：
D O I：
10.1021/jo034098m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efforts to synthesize 4-trifluoromethyl- and 4-difluoromethyl-L-pyroglutamic acids are described. After many arduous efforts, we successfully synthesized our target molecules cis-4-trifluoromethyl-L-pyroglutamic acid 25 and cis-4-difluoromethyl-L-pyroglutamic acid 26 from trams-4-hydroxy-L-proline through oxidation of fluorinated prolinates with RuO4.
引用
收藏
页码：3614 / 3617
页数：4
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