Another brick in the wall

被引：4
作者：
Clarke, Anthony J. [1 ]
机构：
[1] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON, Canada
来源：
NATURE CHEMICAL BIOLOGY | 2017年 / 13卷 / 07期
关键词：
PEPTIDOGLYCAN; PENICILLIN; PROTEINS; FAMILY;
D O I：
10.1038/nchembio.2419
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid II embodies the bricks used to build the essential bacterial cell wall component peptidoglycan. A facile new procedure for preparation of species-specific Lipid II in high yields can now be used to unlock the door to antibiotic discovery.
引用
收藏
页码：695 / 696
页数：3
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共 10 条
  • [1] Observation of the time-course for peptidoglycan lipid intermediate II polymerization by Staphylococcus aureus monofunctional transglycosylase
    Braddick, Darren
    Sandhu, Sandeep
    Roper, David I.
    Chappell, Michael J.
    Bugg, Timothy D. H.
    [J]. MICROBIOLOGY-SGM, 2014, 160 : 1628 - 1636
  • [2] Multimodular penicillin binding proteins: An enigmatic family of orthologs and paralogs
    Goffin, C
    Ghuysen, JM
    [J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1998, 62 (04) : 1079 - +
  • [3] Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan
    Lloyd, Adrian J.
    Gilbey, Andrea M.
    Blewett, Anne M.
    De Pascale, Gianfranco
    El Zoeiby, Ahmed
    Levesque, Roger C.
    Catherwood, Anita C.
    Tomasz, Alexander
    Bugg, Timothy D. H.
    Roper, David I.
    Dowson, Christopher G.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (10) : 6402 - 6417
  • [4] SEDS proteins are a widespread family of bacterial cell wall polymerases
    Meeske, Alexander J.
    Riley, Eammon P.
    Robins, William P.
    Uehara, Tsuyoshi
    Mekalanos, John J.
    Kahne, Daniel
    Walker, Suzanne
    Kruse, Andrew C.
    Bernhardt, Thomas G.
    Rudner, David Z.
    [J]. NATURE, 2016, 537 (7622) : 634 - +
  • [5] Chemical biology of peptidoglycan acetylation and deacetylation
    Moynihan, Patrick J.
    Sychantha, David
    Clarke, Anthony J.
    [J]. BIOORGANIC CHEMISTRY, 2014, 54 : 44 - 50
  • [6] MODE OF ACTION OF PENICILLIN - BIOCHEMICAL BASIS FOR THE MECHANISM OF ACTION OF PENICILLIN AND FOR ITS SELECTIVE TOXICITY
    PARK, JT
    STROMINGER, JL
    [J]. SCIENCE, 1957, 125 (3238) : 99 - 101
  • [7] Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams
    Qiao, Yuan
    Srisuknimit, Veerasak
    Rubino, Frederick
    Schaefer, Kaitlin
    Ruiz, Natividad
    Walker, Suzanne
    Kahne, Daniel
    [J]. NATURE CHEMICAL BIOLOGY, 2017, 13 (07) : 793 - +
  • [8] PEPTIDOGLYCAN TYPES OF BACTERIAL CELL-WALLS AND THEIR TAXONOMIC IMPLICATIONS
    SCHLEIFER, KH
    KANDLER, O
    [J]. BACTERIOLOGICAL REVIEWS, 1972, 36 (04) : 407 - 477
  • [9] Different walls for rods and balls: the diversity of peptidoglycan
    Turner, Robert D.
    Vollmer, Waldemar
    Foster, Simon J.
    [J]. MOLECULAR MICROBIOLOGY, 2014, 91 (05) : 862 - 874
  • [10] Peptidoglycan structure and architecture
    Vollmer, Waldemar
    Blanot, Didier
    de Pedro, Miguel A.
    [J]. FEMS MICROBIOLOGY REVIEWS, 2008, 32 (02) : 149 - 167
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