Myeloperoxidase-463 G/A polymorphism is associated with lung cancer risk: A meta-analysis with 7420 cases and 9132 controls

被引:7
作者
Zou, Shengqiang [1 ,2 ]
Pan, Xin [2 ,3 ]
Hua, Changsong [3 ]
Wu, Min [3 ]
He, Bin [3 ]
Chen, Zhigang [3 ]
机构
[1] Jiangsu Univ, Peoples Hosp Zhenjiang 3, Zhenjiang, Jiangsu, Peoples R China
[2] Jiangsu Univ, Sch Med, Zhenjiang, Jiangsu, Peoples R China
[3] Zhenjiang Emergency Med Ctr, Dept Med Sect, Zhenjiang, Jiangsu, Peoples R China
关键词
Association; lung cancer; myeloperoxidase; polymorphism; SQUAMOUS-CELL CARCINOMA; GENETIC POLYMORPHISMS; REDUCED RISK; MPO; POPULATION; SUSCEPTIBILITY; SMOKING; TISSUE; CYP1A1;
D O I
10.4103/0973-1482.235341
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims: Several studies evaluated the association between myeloperoxidase (MPO) -463 G/A polymorphism and the risk of lung cancer. However, the results were not stable. Materials and Methods: Online electronic databases (PubMed, EMBASE, and Wanfang database) were searched. The strength of association between the MPO -463 G/A polymorphism and lung cancer risk was assessed by calculating odds ratios (OR) with 95% confidence interval (CI). Results: A total of 22 studies with 7420 cases and 9132 controls on the association between MPO -463 G/A polymorphism and lung cancer risk were included for this meta-analysis. MPO -463 G/A polymorphism was associated with a significantly decreased risk of lung cancer (OR = 0.91; 95% CI: 0.85-0.98; I-2 = 25%). In the race subgroup analysis, Asians with MPO -463 G/A polymorphism had decreased lung cancer risk (OR = 0.81; 95% CI: 0.70-0.93; I-2 = 0%). However, Caucasians did not show significant result (OR = 0.93; 95% CI: 0.86-1.02; I-2 = 36%). In the subgroup analysis according to source of control, both population-based studies and hospital-based studies were marginally significantly associated with decreased risk of lung cancer (OR = 0.90; 95% CI: 0.82-1.00; I-2 = 41% and OR = 0.91; 95% CI: 0.82-1.01; I-2 = 0%). Conclusion: The present meta-analysis suggested that the MPO -463 G/A polymorphism carriers had a protective role in lung cancer.
引用
收藏
页码:S282 / S287
页数:6
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