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Ernst Moritz Arndt Univ Greifswald, Med Ernst Moritz Arndt Univ Greifswald, Inst Community Med, Dept Methods Community Med, Walther Rathenau Str 48, D-17487 Greifswald, Germany Heidelberg Univ, Med Hosp, Dept Gen Internal Med & Psychosomat, Neuenheimer Feld 410, D-69120 Heidelberg, Germany