The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins

被引：24

作者：

Santelli, Eugenio

Liddington, Robert C.

Mohan, Michael A.

Hoch, James A.

Szurmant, Hendrik

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USA

[2] Burnham Inst Med Res, Infect & Inflammatory Dis Ctr, La Jolla, CA 92037 USA

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 08期

关键词：

D O I：

10.1128/JB.01937-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

YycI and YycH are two membrane-anchored periplasmic proteins that regulate the essential Bacillus subtilis YycG histidine kinase through direct interaction. Here we present the crystal structure of YycI at a 2.9-angstrom resolution. YycI forms a dimer, and remarkably the structure resembles that of the two C-terminal domains of YycH despite nearly undetectable sequence homology (10%) between the two proteins.

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页码：3290 / 3295

页数：6

相关论文

共 29 条

[1] Methods used in the structure determination of bovine mitochondrial F-1 ATPase [J].

Abrahams, JP ;

Leslie, AGW .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1996, 52 :30-42

[2] Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states [J].

Bent, CJ ;

Isaacs, NW ;

Mitchell, TJ ;

Riboldi-Tunnicliffe, A .

JOURNAL OF BACTERIOLOGY, 2004, 186 (09) :2872-2879

[3] Generation, representation and flow of phase information in structure determination:: recent developments in and around SHARP 2.0 [J].

Bricogne, G ;

Vonrhein, C ;

Flensburg, C ;

Schiltz, M ;

Paciorek, W .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2003, 59 :2023-2030

[4] Crystallography & NMR system:: A new software suite for macromolecular structure determination [J].

Brunger, AT ;

Adams, PD ;

Clore, GM ;

DeLano, WL ;

Gros, P ;

Grosse-Kunstleve, RW ;

Jiang, JS ;

Kuszewski, J ;

Nilges, M ;

Pannu, NS ;

Read, RJ ;

Rice, LM ;

Simonson, T ;

Warren, GL .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1998, 54 :905-921

[5] Algorithms for finding the axis of a helix: Fast rotational and parametric least-squares methods [J].

Christopher, NA ;

Swanson, R ;

Baldwin, TO .

COMPUTERS & CHEMISTRY, 1996, 20 (03) :339-345

[6] Miscellaneous algorithms for density modification [J].

Cowtan, K ;

Main, P .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 1998, 54 :487-493

[7] Motifs of serine and threonine can drive association of transmembrane helices [J].

Dawson, JP ;

Weinger, JS ;

Engelman, DM .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 316 (03) :799-805

[8] Competence repression under oxygen limitation through the two-component MicAB signal-transducing system in Streptococcus pneumoniae and involvement of the PAS domain of MicB [J].

Echenique, JR ;

Trombe, MC .

JOURNAL OF BACTERIOLOGY, 2001, 183 (15) :4599-4608

[9]

Fabret C, 1998, J BACTERIOL, V180, P6375

[10] A census of membrane-bound and intracellular signal transduction proteins in bacteria: Bacterial IQ, extroverts and introverts [J].

Galperin, MY .

BMC MICROBIOLOGY, 2005, 5 (1)