An enzyme-responsive controlled release system based on a dual-functional peptide

被引：17
作者：
Li, X. [1 ,2 ]
Burger, S. [1 ]
O'Connor, A. J. [1 ]
Ong, L. [1 ,2 ,3 ]
Karas, J. A. [2 ,4 ]
Gras, S. L. [1 ,2 ,3 ]
机构：
[1] Univ Melbourne, Dept Chem & Biomol Engn, Particulate Fluids Proc Ctr, Parkville, Vic 3010, Australia
[2] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia
[3] Univ Melbourne, Dept Chem & Biomol Engn, ARC Dairy Innovat Hub, Parkville, Vic 3010, Australia
[4] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 29期
基金：
澳大利亚研究理事会;
关键词：
MELANOCYTE-STIMULATING HORMONE; MESOSTRUCTURED CELLULAR FOAMS; IMMOBILIZED SUBSTRATE; MESOCELLULAR FOAM; SUBTILISIN BPN; SILICA; VARIANTS;
D O I：
10.1039/c5cc10480g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new controlled release system was developed by loading a dual-functional peptide (DFP) on a mesoporous silica material. One-pot synthesis produced a DFP that was stimuli responsive, releasing a therapeutic peptide by protease cleavage. The design provides new steps towards smart biomaterials.
引用
收藏
页码：5112 / 5115
页数：4
相关论文
共 33 条
[1]   PREPARATION AND RECONSTITUTION WITH DIVALENT METAL-IONS OF CLASS-I AND CLASS-II CLOSTRIDIUM-HISTOLYTICUM APOCOLLAGENASES [J].
ANGLETON, EL ;
VANWART, HE .
BIOCHEMISTRY, 1988, 27 (19) :7406-7412
[2]   MILD PROCEDURE FOR SOLID-PHASE PEPTIDE-SYNTHESIS - USE OF "FLUORENYLMETHOXYCARBONYLAMINO-ACIDS [J].
ATHERTON, E ;
FOX, H ;
HARKISS, D ;
LOGAN, CJ ;
SHEPPARD, RC ;
WILLIAMS, BJ .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (13) :537-539
[3]   Blood Clot Initiation by Mesocellular Foams: Dependence on Nanopore Size and Enzyme Immobilization [J].
Baker, Sarah E. ;
Sawvel, April M. ;
Fan, Jie ;
Shi, Qihui ;
Strandwitz, Nicholas ;
Stucky, Galen D. .
LANGMUIR, 2008, 24 (24) :14254-14260
[4]   Micropore Characterization of Mesocellular Foam and Hybrid Organic Functional Mesocellular Foam Materials [J].
Boskovic, Sasha ;
Hill, Anita J. ;
Turney, Terry W. ;
Stevens, Geoffrey W. ;
Gee, Michelle L. ;
O'Connor, Andrea J. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (51) :21283-21292
[5]   SUBTILISIN BPN - ACTIVITY ON AN IMMOBILIZED SUBSTRATE [J].
BRODE, PF ;
RAUCH, DS .
LANGMUIR, 1992, 8 (05) :1325-1329
[6]   Subtilisin BPN' variants: Increased hydrolytic activity on surface-bound substrates via decreased surface activity [J].
Brode, PF ;
Erwin, CR ;
Rauch, DS ;
Barnett, BL ;
Armpriester, JM ;
Wang, ESF ;
Rubingh, DN .
BIOCHEMISTRY, 1996, 35 (10) :3162-3169
[7]   An appraisal of new variants of Dde amine protecting group for solid phase peptide synthesis [J].
Chhabra, SR ;
Hothi, B ;
Evans, DJ ;
White, PD ;
Bycroft, BW ;
Chan, WC .
TETRAHEDRON LETTERS, 1998, 39 (12) :1603-1606
[8]   Kinetics of Enzyme Attack on Substrates Covalently Attached to Solid Surfaces: Influence of Spacer Chain Length, Immobilized Substrate Surface Concentration and Surface Charge [J].
Deere, Joseph ;
De Oliveira, Rui F. ;
Tomaszewski, Bartlomiej ;
Millar, Sarah ;
Lalaouni, Antonia ;
Solares, Laura F. ;
Flitsch, Sabine L. ;
Halling, Peter J. .
LANGMUIR, 2008, 24 (20) :11762-11769
[9]   α-melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells [J].
Elliott, RJ ;
Szabo, M ;
Wagner, MJ ;
Kemp, EH ;
MacNeil, S ;
Haycock, JW .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (04) :1010-1019
[10]   Anti-inflammatory and anti-invasive effects of α-melanocyte-stimulating hormone in human melanoma cells [J].
Eves, P ;
Haycock, J ;
Layton, C ;
Wagner, M ;
Kemp, H ;
Szabo, M ;
Morandini, R ;
Ghanem, G ;
García-Borrón, JC ;
Jiménez-Cervantes, C ;
Mac Neil, S .
BRITISH JOURNAL OF CANCER, 2003, 89 (10) :2004-2015
1234