Estrogen receptor β actions in the female cardiovascular system: A systematic review of animal and human studies

被引：32

作者：

Muka, Taulant ^{[1
]}

Vargas, Kris G. ^{[1
]}

Jaspers, Loes ^{[1
]}

Wen, Ke-xin ^{[1
]}

Dhana, Klodian ^{[1
]}

Vitezova, Anna ^{[1
]}

Nano, Jana ^{[1
]}

Brahimaj, Adela ^{[1
]}

Colpani, Veronica ^{[1
]}

Bano, Arjola ^{[1
]}

Kraja, Bledar ^{[1
,2
,3
]}

Zaciragic, Asija ^{[1
]}

Bramer, Wichor M. ^{[4
]}

van Dijk, Gaby M. ^{[1
]}

Kavousi, Maryam ^{[1
]}

Franco, Oscar H. ^{[1
]}

机构：

[1] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[2] Univ Med, Fac Med, Dept Biomed Sci, Tirana, Albania

[3] Univ Hosp Ctr Mother Teresa, Univ Clin Gastrohepatol, Tirana, Albania

[4] Erasmus MC, Med Lib, Rotterdam, Netherlands

来源：

MATURITAS | 2016年 / 86卷

关键词：

Estrogen receptor beta; Cardiovascular system; Cardiovascular disease; Vascular endothelium; Menopause; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE PRODUCTION; SEX-RELATED DIFFERENCES; SMALL FEMORAL ARTERIES; ER-BETA; HORMONE-THERAPY; GENE-EXPRESSION; VASCULAR INFLAMMATION; SELECTIVE AGONIST;

D O I：

10.1016/j.maturitas.2016.01.009

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Five medical databases were searched for studies that assessed the role of ER beta in the female cardiovascular system and the influence of age and menopause on ER beta functioning. Of 9472 references, 88 studies met our inclusion criteria (71 animal model experimental studies, 15 human model experimental studies and 2 population based studies). ER beta signaling was shown to possess vasodilator and antiangiogenic properties by regulating the activity of nitric oxide, altering membrane ionic permeability in vascular smooth muscle cells, inhibiting vascular smooth muscle cell migration and proliferation and by regulating adrenergic control of the arteries. Also, a possible protective effect of ER beta signaling against left ventricular hypertrophy and ischemia/reperfusion injury via genomic and non-genomic pathways was suggested in 27 studies. Moreover, 5 studies reported that the vascular effects of ER beta may be vessel specific and may differ by age and menopause status. ER beta seems to possess multiple functions in the female cardiovascular system. Further studies are needed to evaluate whether isoform-selective ER beta-ligands might contribute to cardiovascular disease prevention. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：28 / 43

页数：16

共 128 条

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