Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer

被引：17

作者：

Costa, Sandra ^{[1
]}

Pinto, Daniela

Pereira, Deolinda

Vasconcelos, Andre

Afonso-Lopes, Carlos

Osorio, Teresa

Lopes, Carlos

Medeiros, Rui

机构：

[1] Univ Minho, ICVS, Life & Hlth Sci Res Inst, Hlth Sci Sch, P-4710057 Braga, Portugal

[2] Inst Portugues Oncol Francisco Gentil, Mol Oncol Dept Pathol, P-4200072 Oporto, Portugal

[3] Inst Portugues Oncol Francisco Gentil, Dept Med Oncol, P-4200072 Oporto, Portugal

[4] Inst Portugues Oncol Francisco Gentil, Dept Gynecol, P-4200072 Oporto, Portugal

[5] Abel Salazar Inst Biomed Sci, ICBAS, P-4099003 Oporto, Portugal

来源：

CANCER LETTERS | 2007年 / 246卷 / 1-2期

关键词：

XPD; NER; DNA repair; ovarian cancer; polymorphisms;

D O I：

10.1016/j.canlet.2006.03.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR = 2.46 95% CI 1.20-5.06; P = 0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR = 3.40 95% CI 1.61-7.15; P = 0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：324 / 330

页数：7

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