Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial

被引:16
作者
Streese, Lukas [1 ]
Kotliar, Konstantin [2 ]
Deiseroth, Arne [1 ]
Infanger, Denis [1 ]
Gugleta, Konstantin [3 ]
Schmaderer, Christoph [4 ]
Hanssen, Henner [1 ]
机构
[1] Univ Basel, Med Fac, Dept Sport Exercise & Hlth, CH-4052 Basel, Switzerland
[2] Univ Appl Sci, Dept Med Engn & Appl Math, Aachen, Germany
[3] Univ Basel, Dept Ophthalmol, Basel, Switzerland
[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Nephrol, Munich, Germany
基金
瑞士国家科学基金会;
关键词
cardiovascular disease; cerebrovascular health; high-intensity interval training; retinal microcirculation; CORONARY-HEART-DISEASE; ATHEROSCLEROSIS RISK; VASCULAR FUNCTION; SHEAR-STRESS; NITRIC-OXIDE; DYSFUNCTION; DIAMETER; STROKE; INFLAMMATION; PROTOCOLS;
D O I
10.1111/sms.13560
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 +/- 6 years) with >= two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 +/- 2.1%, post: 3.0 +/- 2.2%, P = .018) and AFarea (pre: 32.6 +/- 28.4%*s, post: 37.7 +/- 30.6%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 +/- 1.8%, post: 2.9 +/- 1.8%, P = .254; AFarea, pre: 41.6 +/- 28.5%*s, post: 37.8 +/- 27.0%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between increment -change VO2peak and increment -changes ADmax and AFarea (P = .026, R-2 = 0.073; P = .019, R-2 = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.
引用
收藏
页码:272 / 280
页数:9
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