Efficient stepwise and one pot three-component synthesis of 2-amino-4-(2-oxo-2H-chromen-3-yl)thiophene-3-carbonitriles

被引：21

作者：

Srikrishna, Devulapally ^{[1
]}

Dubey, Pramod Kumar ^{[1
]}

机构：

[1] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Coll Engn, Hyderabad 500085, Telangana, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 48期

关键词：

3-Acetyl-2H-chromen-2-one; Knoevenagel condensation; Elemental sulfur; Gewald reaction; POLYETHYLENE-GLYCOL PEG-400; FACILE; DERIVATIVES;

D O I：

10.1016/j.tetlet.2014.10.021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Environmentally benign conditions have been developed for the synthesis of 2-amino-4-(2-oxo-2H-chromen-3-yl)thiophene-3-carbonitriles (3) starting from 3-acetyl-2H-chromen-2-one (1) through the intermediacy of 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)malononitrile (2) using the Knoevenagel condensation followed by the Gewald reaction. Alternatively, 3 could also be prepared in a one pot method by treating equimolar amounts of 1, malononitrile, and elemental sulfur. The merits of this preparation are mild reaction conditions, easy work-up procedure, and good yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6561 / 6566

页数：6

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