Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals

被引：21
|
作者：
Ito, Hidenori [1 ]
Morishita, Rika [1 ]
Nagata, Koh-ichi [1 ,2 ]
机构：
[1] Aichi Human Serv Ctr, Inst Dev Res, Dept Mol Neurobiol, 713-8 Kamiya, Kasugai, Aichi 4800392, Japan
[2] Nagoya Univ, Grad Sch Med, Dept Neurochem, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 07期
基金：
日本学术振兴会;
关键词：
Rho; Rhotekin; binding partner; MULTIDOMAIN ADAPTER PROTEIN; SYNAPTIC VESICLE EXOCYTOSIS; ELEGANS VULVAL INDUCTION; DIRECTLY TARGETING RTKN; CELL-CELL JUNCTIONS; PDZ-PROTEIN; CYTOSKELETAL ORGANIZATION; DIFFERENTIAL EXPRESSION; BASOLATERAL MEMBRANE; SEPTIN ORGANIZATION;
D O I：
10.3390/ijms19072121
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, two proline-rich regions and a C-terminal PDZ (PSD-95, Discs-large, and ZO-1)-binding motif. We, and other groups, have identified various binding partners for Rhotekin and carried out biochemical and cell biological characterization. However, the physiological functions of Rhotekin, per se, are as of yet largely unknown. In this review, we summarize known features of Rhotekin and its binding partners in neuronal tissues and cancer cells.
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页数：14
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