p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN

被引：20

作者：

Anderson, Deborah H. ^{[1
]}

机构：

[1] Saskatchewan Canc Agcy, Canc Res Unit, Saskatoon, SK, Canada

来源：

CELL CYCLE | 2010年 / 9卷 / 11期

基金：

加拿大健康研究院;

关键词：

p85; regulation; lipid phosphatase; PTEN tumor suppressor; PI3 kinase pathway; protein:protein interactions; explains mouse phenotypes; insulin signaling; PHOSPHATIDYLINOSITOL; 3-KINASE; SUBUNIT; P85-ALPHA; MICE;

D O I：

10.4161/cc.9.11.11926

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：2055 / 2056

页数：2

共 11 条

[1] Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice [J].

Brachmann, SM ;

Ueki, K ;

Engelman, JA ;

Kahn, RC ;

Cantley, LC .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (05) :1596-1607

[2] Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase [J].

Chagpar, Ryaz B. ;

Links, Philip H. ;

Pastor, M. Chris ;

Furber, Levi A. ;

Hawrysh, Andrea D. ;

Chamberlain, M. Dean ;

Anderson, Deborah H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (12) :5471-5476

[3] Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation [J].

Chamberlain, M. Dean ;

Chan, Tim ;

Oberg, Jennifer C. ;

Hawrysh, Andrea D. ;

James, Kristy M. ;

Saxena, Anurag ;

Xiang, Jim ;

Anderson, Deborah H. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (23) :15861-15868

[4] The p85α subunit of phosphatidylinositol 3′-kinase binds to and stimulates the GTPase activity of rab proteins [J].

Chamberlain, MD ;

Berry, TR ;

Pastor, MC ;

Anderson, DH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (47) :48607-48614

[5] Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α [J].

Fruman, DA ;

Mauvais-Jarvis, F ;

Pollard, DA ;

Yballe, CM ;

Brazil, D ;

Bronson, RT ;

Kahn, CR ;

Cantley, LC .

NATURE GENETICS, 2000, 26 (03) :379-382

[6] p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex [J].

Rabinovsky, Rosalia ;

Pochanard, Panisa ;

McNear, Chontelle ;

Brachmann, Saskia M. ;

Duke-Cohan, Jonathan S. ;

Garraway, Levi A. ;

Sellers, William R. .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (19) :5377-5388

[7] Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85α regulatory subunit [J].

Ueki, K ;

Algenstaedt, P ;

Mauvais-Jarvis, F ;

Kahn, CR .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (21) :8035-8046

[8] Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival [J].

Ueki, K ;

Fruman, DA ;

Brachmann, SM ;

Tseng, YH ;

Cantley, LC ;

Kahn, CR .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (03) :965-977

[9] Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex [J].

Vazquez, F ;

Grossman, SR ;

Takahashi, Y ;

Rokas, MV ;

Nakamura, N ;

Sellers, WR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) :48627-48630

[10] Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity [J].

Wong, J. T. ;

Kim, P. T. W. ;

Peacock, J. W. ;

Yau, T. Y. ;

Mui, A. L. -F. ;

Chung, S. W. ;

Sossi, V. ;

Doudet, D. ;

Green, D. ;

Ruth, T. J. ;

Parsons, R. ;

Verchere, C. B. ;

Ong, C. J. .

DIABETOLOGIA, 2007, 50 (02) :395-403

← 1 2 →