Proteomics in clinical chemistry: will it be long?

被引：10

作者：

Lescuyer, Pierre ^{[1
,2
]}

Farina, Annarita ^{[2
]}

Hochstrasser, Denis F. ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Geneva, Clin Prote Lab, Lab Med Serv, Dept Genet & Lab Med, Geneva, Switzerland

[2] Univ Geneva, Biomed Prote Res Grp, Dept Bioinformat & Struct Biol, Fac Med, Geneva, Switzerland

[3] Univ Geneva, Swiss Ctr Appl Human Toxicol, Sch Pharmaceut Sci, Fac Sci, Geneva, Switzerland

来源：

TRENDS IN BIOTECHNOLOGY | 2010年 / 28卷 / 05期

关键词：

FLIGHT MASS-SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; BIOMARKER DISCOVERY; PARATHYROID-HORMONE; PLASMA PROTEOME; HUMAN SERUM; REPRODUCIBILITY; PROTEINS; CANCER; GUIDELINES;

D O I：

10.1016/j.tibtech.2010.02.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Proteomics has stimulated the development of very powerful methods for protein analysis. Implementation of some of these methods in clinical chemistry laboratories could offer clinicians better tools for diagnosis, prognosis and therapeutic follow-up of human diseases. However, laboratory medicine activities are bound by a number of constraints and rules for ensuring quality of results for clinical practice. There is therefore a gap to be filled between the research and routine medical laboratories. In this opinion article, we present the proteomic methods that will most likely be implemented in clinical chemistry laboratories in the short term, and we discuss the major issues yet to be addressed before considering such a transfer.

引用

页码：225 / 229

页数：5

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