A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans

被引:1
|
作者
Tang, Jie [1 ]
Zhang, Jian-Fan [1 ]
Yang, Rui-Qiu [1 ]
Chen, Yuan-Li [3 ]
Ni, Baosen [2 ]
机构
[1] Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650091, Yunnan, Peoples R China
[2] Yuxi Normal Univ, Sch Chem Biol & Environm, Inst Biol & Environm Engn, Yuxi 653100, Peoples R China
[3] Kunming Med Univ, Fac Basic Med, Kunming 650500, Yunnan, Peoples R China
关键词
RNA sequencing; Klo-1; Mpk-1; Longevity; Autophagy; LIFE-SPAN; MICE; SUPPRESSION; RESISTANCE; MUTANT;
D O I
10.1016/j.bbrc.2021.05.042
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There are six different longevity models in Caenorhabditis elegans. Previous studies have identified several convergence points, such as hlh-30, daf-16, and klf-3, required for lifespan extension in these longevity models. However, it is not clear whether there other such convergence points. In this study, based on analysis of transcriptome data, we found that the expression of klo-1/klotho was elevated in several longevity models. klo-1 was required for lifespan extension in the glp-1(e2141) and isp-1(qm150) mutants. klo-1 extended the lifespan of glp-1(e2141) and isp-1(qm150) worms by activating extracellular-signal-regulated kinase (ERK). In addition, klo-1 and mpk-1 (the homologous gene encoding ERK) regulated autophagy in glp-1(e2141) mutants, suggesting that klo-1 regulates lifespan by activating autophagy. (c) 2021 Published by Elsevier Inc.
引用
收藏
页码:36 / 42
页数:7
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