Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphoma

被引:21
作者
Bhatt, Vijaya Raj [1 ]
Vose, Julie M. [1 ]
机构
[1] Univ Nebraska Med Ctr, Dept Internal Med, Div Hematol Oncol, Omaha, NE 68198 USA
关键词
Non-Hodgkin lymphoma; Diffuse large B-cell lymphoma; Follicular lymphoma; Mantle cell lymphoma; Peripheral T-cell lymphoma; Autologous hematopoietic stem cell transplantation; Allogeneic hematopoietic stem cell transplantation; HIGH-DOSE THERAPY; PROGRESSION-FREE SURVIVAL; INTERNATIONAL PROGNOSTIC INDEX; DETUDE DES LYMPHOMES; RITUXIMAB MAINTENANCE THERAPY; ADVANCED FOLLICULAR LYMPHOMA; BONE-MARROW-TRANSPLANTATION; LONG-TERM SURVIVAL; PHASE-II TRIAL; T-CELL;
D O I
10.1016/j.hoc.2014.08.015
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Up-front rituximab-based chemotherapy has improved outcomes in non-Hodgkin lymphoma (NHL); refractory or relapsed NHL still accounts for approximately 18,000 deaths in the United States. Autologous hematopoietic stem cell transplantation (SCT) can improve survival in primary refractory or relapsed aggressive NHL and mantle cell lymphoma and in relapsed follicular or peripheral T-cell lymphoma. Autologous SCT as a consolidation therapy after first complete or partial remission in high-risk aggressive NHL, mantle cell lymphoma, and peripheral T-cell lymphoma may improve progression-free survival. Allogeneic SCT offers a lower relapse rate but a higher nonrelapse mortality resulting in overall survival similar to autologous SCT.
引用
收藏
页码:1073 / +
页数:24
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