Comparative analysis of two-component signal transduction system in two streptomycete genomes

被引：6

作者：

Wei, Wu

Wang, Weihua

Cao, Zhiwei

Yu, Hong

Wang, Xiaojing

Zhao, Jing

Tan, Hao

Xu, Hao

Jiang, Weihong ^{[1
]}

Li, Yixue

机构：

[1] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Syst Biol,Bioinformat Ctr, Shanghai 200031, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Inst Plant Physiol & Ecol,Lab Mol Microbiol, Shanghai 200032, Peoples R China

[3] Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2007年 / 39卷 / 05期

关键词：

Streptomyces; two-component system; cross-talk; phylogenetic analysis;

D O I：

10.1111/j.1745-7270.2007.00282.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Species of the genus Streptomyces are major bacteria responsible for producing most natural antibiotics. Streptomyces coelicolor A3(2) and Streptomyces avermitilis were sequenced in 2002 and 2003, respectively. Two-component signal transduction systems (TCSs), consisting of a histidine sensor kinase (SK) and a cognate response regulator (RR), form the most common mechanism of transmembrane signal transduction in prokaryotes. TCSs in S. coelicolor A3(2) have been analyzed in detail. Here, we identify and classify the SK and RR of S. avermitilis and compare the TCSs with those of S. coelicolor A3(2) by computational approaches. Phylogenetic analysis of the cognate SK-RR pairs of the two species indicated that the cognate SK-RR pairs fall into four classes according to the distribution of their orthologs in other organisms. In addition to the cognate SK-RR pairs, some potential partners of non-cognate SK-RR were found, including those of unpaired SK and orphan RR and the cross-talk between different components in either strain. Our study provides new clues for further exploration of the molecular regulation mechanism of streptomycetes with industrial importance.

引用

页码：317 / 325

页数：9

共 28 条

[1]

[Anonymous], 2000, Practical Streptomyces genetics, DOI DOI 10.1111/J.1365-2427.2007.01876.X

[2]

[Anonymous], 1989, Cladistics, DOI DOI 10.1111/J.1096-0031.1989.TB00562.X

[3] The GAF domain: an evolutionary link between diverse phototransducing proteins [J].

Aravind, L ;

Ponting, CP .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (12) :458-459

[4] Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].

Bentley, SD ;

Chater, KF ;

Cerdeño-Tárraga, AM ;

Challis, GL ;

Thomson, NR ;

James, KD ;

Harris, DE ;

Quail, MA ;

Kieser, H ;

Harper, D ;

Bateman, A ;

Brown, S ;

Chandra, G ;

Chen, CW ;

Collins, M ;

Cronin, A ;

Fraser, A ;

Goble, A ;

Hidalgo, J ;

Hornsby, T ;

Howarth, S ;

Huang, CH ;

Kieser, T ;

Larke, L ;

Murphy, L ;

Oliver, K ;

O'Neil, S ;

Rabbinowitsch, E ;

Rajandream, MA ;

Rutherford, K ;

Rutter, S ;

Seeger, K ;

Saunders, D ;

Sharp, S ;

Squares, R ;

Squares, S ;

Taylor, K ;

Warren, T ;

Wietzorrek, A ;

Woodward, J ;

Barrell, BG ;

Parkhill, J ;

Hopwood, DA .

NATURE, 2002, 417 (6885) :141-147

[5]

Chang HM, 1996, MOL MICROBIOL, V21, P1075

[6]

CHATER KF, 1993, ANNU REV MICROBIOL, V47, P685, DOI 10.1146/annurev.mi.47.100193.003345

[7] Multiple sequence alignment with the Clustal series of programs [J].

Chenna, R ;

Sugawara, H ;

Koike, T ;

Lopez, R ;

Gibson, TJ ;

Higgins, DG ;

Thompson, JD .

NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3497-3500

[8]

CLAROS MG, 1994, COMPUT APPL BIOSCI, V10, P685

[9] Profile hidden Markov models [J].

Eddy, SR .

BIOINFORMATICS, 1998, 14 (09) :755-763

[10] Two-component signal transduction in Bacillus subtilis:: How one organism sees its world [J].

Fabret, C ;

Feher, VA ;

Hoch, JA .

JOURNAL OF BACTERIOLOGY, 1999, 181 (07) :1975-1983

← 1 2 3 →