ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

被引：1382

作者：

Blackford, Andrew N. ^{[1
,2
,3
,4
,5
]}

Jackson, Stephen P. ^{[4
,5
,6
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] Univ Oxford, Canc Res UK, Oxford OX3 7DQ, England

[3] Univ Oxford, Med Res Council Oxford Inst Radiat Oncol, Dept Oncol, Oxford OX3 7DQ, England

[4] Univ Cambridge, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QN, England

[5] Univ Cambridge, Canc Res UK Gurdon Inst, Tennis Court Rd, Cambridge CB2 1QN, England

[6] Univ Cambridge, Dept Biochem, Tennis Court Rd, Cambridge CB2 1GA, England

来源：

MOLECULAR CELL | 2017年 / 66卷 / 06期

基金：

英国惠康基金;

关键词：

DEPENDENT PROTEIN-KINASE; STRAND-BREAK-REPAIR; ATAXIA-TELANGIECTASIA GENE; REPLICATION FORK COLLAPSE; CELL-CYCLE REGULATION; CATALYTIC SUBUNIT; SCHIZOSACCHAROMYCES-POMBE; V(D)J RECOMBINATION; IONIZING-RADIATION; INDUCED PHOSPHORYLATION;

D O I：

10.1016/j.molcel.2017.05.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established functions in sensing and responding to genotoxic stress. We also highlight what is known regarding their structural similarities andcommon mechanisms of regulation, as well asemerging non-canonical roles and how our knowledge of ATM, ATR, and DNA-PK is being translated to benefit human health.

引用

页码：801 / 817

页数：17

共 269 条

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