Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis

被引：419

作者：

Zuo, Zhiwei ^{[1
]}

Gong, Huan ^{[2
]}

Li, Wei ^{[1
]}

Choi, Junwon ^{[2
]}

Fu, Gregory C. ^{[2
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA

[2] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 06期

关键词：

SUZUKI CROSS-COUPLINGS; MERGING PHOTOREDOX; CARBOXYLIC-ACIDS; LIGHT; ACTIVATION; CONVERSION; IMPROVE;

D O I：

10.1021/jacs.5b13211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An asymmetric decarboxylative C-sp(3)-C-sp(2) cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant alpha-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.

引用

页码：1832 / 1835

页数：4

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