Mucuna sanjappae Aitawade et Yadav: a new species of Mucuna with promising yield of anti-Parkinson's drug L-DOPA

被引:12
作者
Patil, R. R. [1 ,2 ]
Gholave, A. R. [3 ]
Jadhav, J. P. [1 ,2 ]
Yadav, S. R. [3 ]
Bapat, V. A. [2 ]
机构
[1] Shivaji Univ, Dept Biochem, Kolhapur 416004, Maharashtra, India
[2] Shivaji Univ, Dept Biotechnol, Kolhapur 416004, Maharashtra, India
[3] Shivaji Univ, Dept Bot, Kolhapur 416004, Maharashtra, India
关键词
L-DOPA; Mucuna sanjappae; Parkinson's disease; ACID;
D O I
10.1007/s10722-014-0164-8
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
Mucuna is a well-known medicinal and food plant widely exploited for its seed pods and leaves in many tropical countries. The drug L-3, 4-dihydroxyphenylalanine (L-DOPA) extracted from seeds of Mucuna plant has been commonly used in the treatment of Parkinson's disease. In the present study, a new species of Mucuna, M. sanjappae Aitawade et Yadav from north-Western Ghats of India, has been analyzed for the presence of L-DOPA and a reasonable level of this drug (7.3 %) was detected. The necessary biochemical characterization of the seeds extract of this plant showed nutritional and anti-nutritional components. Simultaneously, moisture, ash, dietary fiber, calorific value, nitrate and mineral contents of seeds were also determined. This new plant species will be a potential candidate for extraction of L-DOPA and will be a good addition to the existing natural sources of anti-Parkinson's drug since demand for L-DOPA is continuously escalating.
引用
收藏
页码:155 / 162
页数:8
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