HYPOTHALAMIC INFLAMMATION AND OBESITY

被引：16

作者：

Araujo, Eliana P. ^{[1
]}

Torsoni, Marcio A. ^{[2
]}

Velloso, Licio A. ^{[2
]}

机构：

[1] FCM UNICAMP, Dept Nursing, Sao Paulo, Brazil

[2] FCM UNICAMP, Lab Cell Signaling, Sao Paulo, Brazil

来源：

HORMONES OF THE LIMBIC SYSTEM | 2010年 / 82卷

关键词：

MELANIN-CONCENTRATING HORMONE; ENDOPLASMIC-RETICULUM STRESS; BODY-WEIGHT; FOOD-INTAKE; LEPTIN RESISTANCE; INSULIN-RECEPTOR; ER STRESS; KAPPA-B; ACTIVATION; NEURONS;

D O I：

10.1016/S0083-6729(10)82007-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is one of the most prevalent diseases in the modern world. It results from the progressive loss of balance between food intake and whole body energy expenditure. Recent studies have shown that consumption of fat-rich diets induces hypothalamic inflammation and dysfunction which is characterized by defective response to anorexygenic and thermogenic hormones, such as leptin and insulin, leading to anomalous neurotransmitter production and favoring body mass gain. In this chapter, we present the main recent advances in this rapidly evolving field, focusing on the role of hypothalamic inflammation on the genesis of obesity. (C) 2010 Elsevier Inc.

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收藏

页码：129 / 143

页数：15

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