Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

被引：18

作者：

Martinez Perez-Crespo, Pedro Maria ^{[1
,2
]}

Felipe Lanz-Garcia, Joaquin ^{[1
]}

Bravo-Ferrer, Jose ^{[1
]}

Luisa Canton-Bulnes, Maria ^{[3
]}

Sousa Dominguez, Adrian ^{[4
]}

Goikoetxea Aguirre, Josune ^{[5
]}

Maria Reguera-Iglesias, Jose ^{[6
]}

Leon Jimenez, Eva ^{[2
]}

Arminanzas Castillo, Carlos ^{[7
]}

Mantecon Vallejo, Maria Angeles ^{[8
]}

Marrodan Ciordia, Teresa ^{[9
]}

Fernandez Suarez, Jonathan ^{[10
]}

Boix-Palop, Lucia ^{[11
]}

Cuquet Pedragosa, Jordi ^{[12
]}

Jover Saenz, Alfredo ^{[13
]}

Sevilla Blanco, Juan ^{[14
]}

Galan-Sanchez, Fatima ^{[15
]}

Natera Kindelan, Clara ^{[16
]}

del Arco Jimenez, Alfonso ^{[17
]}

Bahamonde-Carrasco, Alberto ^{[18
]}

Smithson Amat, Alejandro ^{[19
]}

Vinuesa Garcia, David ^{[20
]}

Herrero Rodriguez, Carmen ^{[21
]}

Reche Molina, Isabel Maria ^{[22
]}

Perez Camacho, Ines ^{[23
]}

Sanchez-Porto, Antonio ^{[24
]}

Guzman Garcia, Marcos ^{[25
]}

Becerril Carral, Berta ^{[26
]}

Merino de Lucas, Esperanza ^{[27
]}

Lopez-Hernandez, Inmaculada ^{[1
]}

Rodriguez-Bano, Jesus ^{[1
]}

Eduardo Lopez-Cortes, Luis ^{[1
]}

机构：

[1] Univ Seville, Hosp Univ Virgen Macarena, Unidad Clin Enfermedades Infecciosas Microbiol &, Dept Med,Inst Biomed Sevilla, Seville, Spain

[2] Hosp Univ Nuestra Senora Valme, Unidad Enfermedades Infecciosas & Microbiol, Seville, Spain

[3] Hosp Univ Virgen Macarena, Unidad Cuidados Intensivos, Seville, Spain

[4] Hosp Alvaro Cunqueiro, Serv Med Interna, Unidad Enfermedades Infecciosas, Vigo, Spain

[5] Hosp Univ Cruces, Unidad Enfermedades Infecciosas, Bizkaia, Spain

[6] Hosp Reg Univ Malaga, Serv Enfermedades Infecciosas, IBIMA Malaga, Malaga, Spain

[7] Univ Cantabria, Hosp Univ Marques de Valdecilla, IDIVAL, Unidad Enfermedades Infecciosas, Santander, Spain

[8] Hosp Univ Burgos, Unidad Gest Clin Enfermedades Infecciosas, Burgos, Spain

[9] Complejo Asistencial Univ Leon CAULE, Dept Microbiol Clin, Leon, Spain

[10] Hosp Univ Cent Asturias, Inst Invest Sanitaria Principado Asturias ISPA, Unidad Microbiol, Oviedo, Spain

[11] Hosp Univ Mutua Terrassa, Serv Med Interna, Unidad Enfermedades Infecciosas, Barcelona, Spain

[12] Hosp Univ Granollers, Dept Med Interna, Granollers, Spain

[13] Hosp Arnau Vilanova, Unidad Func Infecc Nosocomiales, Lerida, Spain

[14] Hosp Univ Jerez de la Frontera, Unidad Gest Clin Enfermedades Infecciosas & Micro, Jerez de la Frontera, Spain

[15] Hosp Univ Puerta Mar, Unidad Gest Clin Microbiol, Cadiz, Spain

[16] Hosp Univ Reina Sofia, Unidad Clin Enfermedades Infecciosas, Cordoba, Spain

[17] Hosp Costa Sol, Serv Med Interna, Grp Enfermedades Infecciosas, Marbella, Spain

[18] Hosp El Bierzo, Dept Med Interna, Ponferrada, Spain

[19] Fundacio Hosp Esperit St, Unidad Med Interna, Santa Coloma De Gramenet, Spain

[20] Hosp Univ Clin San Cecilio, Unidad Gest Clin Enfermedades Infecciosas, Granada, Spain

[21] Complejo Hosp Jaen, Unidad Gest Clin Enfermedades Infecciosas & Micro, Jaen, Spain

[22] Hosp Univ Torrecardenas, Unidad Enfermedades Infecciosas, Almeria, Spain

[23] Hosp Gen Poniente, Unidad Med Trop, El Ejido, Spain

[24] Hosp la Linea de la Concepcion, Unidad Enfermedades Infecciosas & Microbiol, La Linea De Concepcion, Spain

[25] Hosp San Juan de la Cruz, Serv Med Interna, Ubeda, Spain

[26] Area Sanitaria Campo Gibraltar, Unidad Clin Gest Enfermedades Infecciosas & Micro, Cadiz, Spain

[27] Hosp Univ Gen Alicante, Unidad Enfermedades Infecciosas, Alicante, Spain

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2021年 / 58卷 / 01期

关键词：

Bacteraemia; Bloodstream infection; Aetiology; Epidemiology; Healthcare-associated; ANTIBIOTIC-THERAPY; WESTERN INTERIOR; BRITISH-COLUMBIA; BACTEREMIA; COMMUNITY; BURDEN; MORTALITY; DEFINITIONS; SEPSIS; TRENDS;

D O I：

10.1016/j.ijantimicag.2021.106352

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60-81 years) and 3656 (58.3%; 95% confidence interval 57.1-59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients' profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition. (C) 2021 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.

引用

页数：8

共 22 条

[21] Multinational Prospective Cohort Study of Mortality Risk Factors in 198 ICUs of 12 Latin American Countries over 24 Years: The Effects of Healthcare-Associated Infections
Rosenthal, Victor Daniel
Yin, Ruijie
Liliana Valderrama-Beltran, Sandra
Milena Gualtero, Sandra
Yaneth Linares, Claudia
Aguirre-Avalos, Guadalupe
Cesar Mijangos-Mendez, Julio
Angel Ibarra-Estrada, Miguel
Fernanda Jimenez-Alvarez, Luisa
Patricia Reyes, Lidia
Arturo Alvarez-Moreno, Carlos
Adelia Zuniga-Chavarria, Maria
Marcela Quesada-Mora, Ana
Gomez, Katherine
Alarcon, Johana
Millan Onate, Jose
Aguilar-De-Moros, Daisy
Castano-Guerra, Elizabeth
Cordoba, Judith
Sassoe-Gonzalez, Alejandro
Marisol Millan-Castillo, Claudia
Leyva Xotlanihua, Lissette
Alejandra Aguilar-Moreno, Lina
Bravo Ojeda, Juan Sebastian
Gutierrez Tobar, Ivan Felipe
Cruz Aleman-Bocanegra, Mary
Veronica Echazarreta-Martinez, Clara
Mireya Flores-Sanchez, Belinda
Andrea Cano-Medina, Yuliana
Giovannny Chapeta-Parada, Edwin
Antonio Gonzalez-Nino, Rafael
Isabel Villegas-Mota, Maria
Montoya-Malvaez, Mildred
Angel Cortes-Vazquez, Miguel
Medeiros, Eduardo Alexandrino
Fram, Dayana
Vieira-Escudero, Daniela
Jin, Zhilin
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH, 2022, 12 (04) : 504 - 515
[22] Determinants of morbidity and mortality related to health care-associated primary bloodstream infections in neonatal intensive care units: a prospective cohort study from the SEPREVEN trial
Jaloustre, Morgane
Cohen, Robert
Biran, Valerie
Decobert, Fabrice
Layese, Richard
Audureau, Etienne
Le Sache, Nolwenn
Chevallier, Marie
Boukhris, Mohamed Riadh
Bolot, Pascal
Caeymaex, Laurence
Tauzin, Manon
FRONTIERS IN PEDIATRICS, 2023, 11

← 1 2 3 →