The Impact of 68Gallium DOTA PET/CT in Managing Patients With Sporadic and Familial Pancreatic Neuroendocrine Tumours

被引：22

作者：

Cuthbertson, Daniel J. ^{[1
,2
]}

Barriuso, Jorge ^{[3
,4
]}

Lamarca, Angela ^{[3
,4
]}

Manoharan, Prakash ^{[5
]}

Westwood, Thomas ^{[5
]}

Jaffa, Matthew ^{[1
]}

Fenwick, Stephen W. ^{[1
]}

Nuttall, Christina ^{[4
]}

Lalloo, Fiona ^{[6
]}

Prachalias, Andreas ^{[7
]}

Pizanias, Michail ^{[7
]}

Wieshmann, Hulya ^{[1
]}

McNamara, Mairead G. ^{[3
,4
]}

Hubner, Richard ^{[3
,4
]}

Srirajaskanthan, Raj ^{[8
]}

Vivian, Gillian ^{[8
]}

Ramage, John ^{[8
]}

Weickert, Martin O. ^{[9
]}

Pritchard, D. Mark ^{[1
,2
]}

Vinjamuri, Sobhan ^{[1
]}

Valle, Juan ^{[3
,4
]}

Yip, Vincent S. ^{[10
,11
]}

机构：

[1] Liverpool Univ Hosp NHS Fdn Trust, ENETS Ctr Excellence, Liverpool, Merseyside, England

[2] Univ Liverpool, Fac Hlth & Life Sci, Liverpool, Merseyside, England

[3] Univ Manchester, Div Canc Sci, Manchester, Lancs, England

[4] Christie NHS Fdn Trust, Dept Med Oncol, ENETS Ctr Excellence, Manchester, Lancs, England

[5] Christie NHS Fdn Trust, Dept Radiol & Nucl Med, ENETS Ctr Excellence, Manchester, Lancs, England

[6] Cent Manchester Univ Hosp NHS Fdn Trust, Dept Clin Genet, Manchester Ctr Genom Med, St Marys Hosp, Manchester, Lancs, England

[7] Kings Coll Hosp London, Inst Liver Studies, London, England

[8] Kings Coll Hosp London, Inst Liver Studies, KHP ENETS Ctr Excellence, Neuroendocrine Tumour Unit, London, England

[9] Univ Hosp Coventry & Warwickshire, ENETS Ctr Excellence, Arden Neuroendocrine Ctr, Coventry, W Midlands, England

[10] Royal London Hosp, Barts & London HPB Ctr, London, England

[11] Royal Liverpool Univ Hosp, Dept Pancreatobiliary Surg, Liverpool, Merseyside, England

来源：

FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷

关键词：

pancreatic neuroendocrine tumours; (68)Gallium DOTA PET; CT; functional imaging; multiple endocrine neoplasia type 1; sporadic and familial; ENETS CONSENSUS GUIDELINES; GA-68-DOTATATE PET/CT; MANAGEMENT; UPDATE; EPIDEMIOLOGY; POPULATION; EXPERIENCE; DIAGNOSIS;

D O I：

10.3389/fendo.2021.654975

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective Pancreatic neuroendocrine tumours (panNETs) arise sporadically or as part of a genetic predisposition syndrome. CT/MRI, endoscopic ultrasonography and functional imaging using Octreoscan localise and stage disease. This study aimed to evaluate the complementary role of (68)Gallium (Ga-68)-DOTA PET/CT in managing patients with panNETs. Design A retrospective study conducted across three tertiary UK NET referral centres. Methods Demographic, clinical, biochemical, cross-sectional and functional imaging data were collected from patients who had undergone a Ga-68-DOTA PET/CT scan for a suspected panNET. Results We collected data for 183 patients (97 male): median (SD) age 63 (14.9) years, 89.1 vs. 9.3% (n=163 vs. 17) alive vs. dead (3 data missing), 141 sporadic vs. 42 familial (MEN1, n=36; 85.7%) panNETs. Non-functional vs. functional tumours comprised 73.2 vs. 21.3% (n=134 vs. 39) (10 missing). Histological confirmation was available in 89% of individuals (n=163) but tumour grading (Ki67 classiifcation) was technically possible only in a smaller cohort (n=143): grade 1, 50.3% (n=72); grade 2, 46.2% (n=66) and grade 3, 3.5% (n=5) (40 histopathological classification either not technically feasible or biopsy not perfomed). 60.1% (n=110) were localised, 14.2% (n=26) locally advanced and 23.5% (n=43) metastatic (4 missing). 224 Ga-68-DOTA PET/CT scans were performed in total for: diagnosis/staging 40% (n=88), post-operative assessment/clinical surveillance 53% (n=117) and consideration of peptide receptor radionuclide therapy (PRRT) 8% (n=17) (2 missing). PET/CT results confirmed other imaging findings (53%), identified new disease sites (28.5%) and excluded suspected disease (5%). Overall, Ga-68-DOTA PET/CT imaging findings provided additional information in 119 (54%) patients and influenced management in 85 (39%) cases. Conclusion Ga-68-DOTA PET/CT imaging more accurately stages and guides treatment in patients with sporadic/familial panNETs with newly diagnosed/recurrent disease.

引用

页数：10

共 42 条

[1] Limited Value of Ga-68-DOTATOC-PET-CT in Routine Screening of Patients with Multiple Endocrine Neoplasia Type 1 [J].