Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

被引：124

作者：

Gharbharan, Arvind ^{[1
]}

Jordans, Carlijn C. E. ^{[1
]}

GeurtsvanKessel, Corine ^{[1
]}

den Hollander, Jan G. ^{[2
]}

Karim, Faiz ^{[3
]}

Mollema, Femke P. N. ^{[4
]}

Stalenhoef-Schukken, Janneke E. ^{[5
]}

Dofferhoff, Anthonius ^{[6
]}

Ludwig, Inge ^{[7
]}

Koster, Adrianus ^{[8
]}

Hassing, Robert-Jan ^{[9
]}

Bos, Jeannet C. ^{[10
]}

van Pottelberge, Geert R. ^{[11
]}

Vlasveld, Imro N. ^{[12
]}

Ammerlaan, Heidi S. M. ^{[13
]}

Leeuwen-Segarceanu, Elena M. van ^{[14
]}

Miedema, Jelle ^{[1
]}

van der Eerden, Menno ^{[1
]}

Schrama, Thijs J. ^{[1
]}

Papageorgiou, Grigorios ^{[1
]}

te Boekhorst, Peter ^{[1
]}

Swaneveld, Francis H. ^{[15
]}

Mueller, Yvonne M. ^{[1
]}

Schreurs, Marco W. J. ^{[1
]}

van Kampen, Jeroen J. A. ^{[1
]}

Rockx, Barry ^{[1
]}

Okba, Nisreen M. A. ^{[1
]}

Katsikis, Peter D. ^{[1
]}

Koopmans, Marion P. G. ^{[1
]}

Haagmans, Bart L. ^{[1
]}

Rokx, Casper ^{[1
]}

Rijnders, Bart J. A. ^{[1
]}

机构：

[1] Univ Med Ctr, Erasmus MC, Rotterdam, Netherlands

[2] Maasstad Hosp, Rotterdam, Netherlands

[3] Groene Hart Hosp, Gouda, Netherlands

[4] Haaglanden Med Ctr, The Hague, Netherlands

[5] OLVG Hosp, Amsterdam, Netherlands

[6] Canisius Wilhelmina Hosp, Nijmegen, Netherlands

[7] Bernhoven Hosp, Uden, Netherlands

[8] Viecuri Med Ctr, Venlo, Netherlands

[9] Rijnstate Hosp, Arnhem, Netherlands

[10] Reinier de Graaf Gasthuis, Delft, Netherlands

[11] ZorgSaam Hosp, Terneuzen, Netherlands

[12] Martini Hosp, Groningen, Netherlands

[13] Catharina Hosp, Eindhoven, Netherlands

[14] St Antonius Hosp, Nieuwegein, Netherlands

[15] Sanquin Blood Supply, Unit Transfus Med, Amsterdam, Netherlands

来源：

NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期

关键词：

COVID-19; PREVENTION; THERAPY;

D O I：

10.1038/s41467-021-23469-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS-CoV-2 antibodies, no overall clinical benefit was observed. Using a comprehensive translational approach, we unravel the virological and immunological responses following treatment to disentangle which COVID-19 patients may benefit and should be the focus of future studies. Convalescent plasma is safe, does not improve survival, has no effect on the disease course, nor does plasma enhance viral clearance in the respiratory tract, influence SARS-CoV-2 antibody development or serum proinflammatory cytokines levels. Here, we show that the vast majority of patients already had potent neutralizing SARS-CoV-2 antibodies at hospital admission and with comparable titers to carefully selected plasma donors. This resulted in the decision to terminate the trial prematurely. Treatment with convalescent plasma should be studied early in the disease course or at least preceding autologous humoral response development. There are currently no drugs available to treat SARS-CoV-2 infection. A promising alternative treatment for COVID-19 patients is convalescent plasma. Here, Gharbharan et al. collect covalescent plasma and report no overall clinical benefit for 86 patients hospitalized for COVID-19 and treated with 300mL convalescent plasma.

引用

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