AlCl3-induced (hetero)arylation of thienopyrimidine ring: a new synthesis of 4-substituted thieno[2,3-d]pyrimidines

被引：23

作者：

Kumar, K. Shiva ^{[1
]}

Chamakuri, Srinivas ^{[1
]}

Vishweshwar, Peddy ^{[2
]}

Iqbal, Javed ^{[1
]}

Pal, Manojit ^{[1
]}

机构：

[1] Univ Hyderabad Campus, Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India

[2] Aurigene Discovery Technol Ltd, Pharmaceut Dev, Hyderabad 500049, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 25期

关键词：

BINDING-PROPERTIES; RECEPTOR LIGANDS; SELECTIVE; 5-HT3; AGENTS; DESIGN;

D O I：

10.1016/j.tetlet.2010.04.057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

AlCl3 facilitated C-C bond forming reaction between 4-chloro-thieno[2,3-d]pyrimidines and (hetero)arenes affording a direct and single-step method for the synthesis of 4-(hetero)aryl substituted thieno[2,3-d]pyrimidines. A number of novel thienopyrimidines were prepared in good to excellent yields using this methodology. The molecular structure of a representative compound was established unambiguously by single crystal X-ray diffraction. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3269 / 3273

页数：5

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