Exosomes and the Prion Protein: More than One Truth

被引：63

作者：

Hartmann, Alexander ^{[1
]}

Muth, Christiane ^{[1
]}

Dabrowski, Oliver ^{[2
]}

Krasemann, Susanne ^{[1
]}

Glatzel, Markus ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Neuropathol, Ctr Diagnost, Hamburg, Germany

[2] Ctr Appl Nanotechnol GmbH, Hamburg, Germany

来源：

FRONTIERS IN NEUROSCIENCE | 2017年 / 11卷

关键词：

prion; exosome; micro vesicle; extracellular vesicle; neurodegeneration; beta-amyloid; prion disease; Alzheimer's disease; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY; CREUTZFELDT-JAKOB-DISEASE; AMYLOID-BETA; EXTRACELLULAR VESICLES; ALZHEIMERS-DISEASE; PLASMA EXOSOMES; MOUSE-BRAIN; IN-VIVO; RELEASE; MICE;

D O I：

10.3389/fnins.2017.00194

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exosomes are involved in the progression of neurodegenerative diseases. The cellular prion protein (PrPC) is highly expressed on exosomes. In neurodegenerative diseases, PrPC has at least two functions: It is the substrate for the generation of pathological prion protein (PrPSc), a key player in the pathophysiology of prion diseases. On the other hand, it binds neurotoxic amyloid-beta (A beta) oligomers, which are associated with initiation and progression of Alzheimer's disease (AD). This has direct consequences for the role of exosomal expressed PrPC. In prion diseases, exosomal PrP leads to efficient dissemination of pathological prion protein, thus promoting spreading and transmission of the disease. In AD, exosomal PrPC can bind and detoxify A beta oligomers thus acting protective. In both scenarios, assessment of the state of PrPC on exosomes derived from blood or cerebrospinal fluid (CSF) may be useful for diagnostic workup of these diseases. This review sums up current knowledge of the role of exosomal PrPC on different aspects of Alzheimer's and prion disease.

引用

页数：7

共 72 条

[11] Prion protein at the crossroads of physiology and disease [J].

Biasini, Emiliano ;

Turnbaugh, Jessie A. ;

Unterberger, Ursula ;

Harris, David A. .

TRENDS IN NEUROSCIENCES, 2012, 35 (02) :92-103

[12] Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation [J].

Bobrie, Angelique ;

Colombo, Marina ;

Krumeich, Sophie ;

Raposo, Graca ;

Thery, Clotilde .

JOURNAL OF EXTRACELLULAR VESICLES, 2012, 1 (01)

[13] Are prions transported by plasma exosomes? [J].

Cervenakoya, Larisa ;

Saa, Paula ;

Yakoyleva, Oksana ;

Vasilyeva, Irina ;

de Castro, Jorge ;

Brown, Paul ;

Dodd, Roger .

TRANSFUSION AND APHERESIS SCIENCE, 2016, 55 (01) :70-83

[14] Size and shape characterization of hydrated and desiccated exosomes [J].

Chernyshev, Vasiliy S. ;

Rachamadugu, Rakesh ;

Tseng, Yen Hsun ;

Belnap, David M. ;

Jia, Yunlu ;

Branch, Kyle J. ;

Butterfield, Anthony E. ;

Pease, Leonard F., III ;

Bernard, Philip S. ;

Skliar, Mikhail .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2015, 407 (12) :3285-3301

[15] Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease [J].

Collins, S. J. ;

Sanchez-Juan, P. ;

Masters, C. L. ;

Klug, G. M. ;

van Duijn, C. ;

Poleggi, A. ;

Pocchiari, M. ;

Almonti, S. ;

Cuadrado-Corrales, N. ;

de Pedro-Cuesta, J. ;

Budka, H. ;

Gelpi, E. ;

Glatzel, M. ;

Tolnay, M. ;

Hewer, E. ;

Zerr, I. ;

Heinemann, U. ;

Kretszchmar, H. A. ;

Jansen, G. H. ;

Olsen, E. ;

Mitrova, E. ;

Alperovitch, A. ;

Brandel, J. -P. ;

Mackenzie, J. ;

Murray, K. ;

Will, R. G. .

BRAIN, 2006, 129 :2278-2287

[16] BACE-1 is expressedin the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease [J].

Devraj, Kavi ;

Poznanovic, Slobodan ;

Spahn, Christoph ;

Schwall, Gerhard ;

Harter, Patrick N. ;

Mittelbronn, Michel ;

Antoniello, Katia ;

Paganetti, Paolo ;

Muhs, Andreas ;

Heilemann, Mike ;

Hawkins, Richard A. ;

Schrattenholz, Andre ;

Liebner, Stefan .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 36 (07) :1281-1294

[17] Senescence and extracellular vesicles: novel partners in vascular amyloidosis [J].

Whitehead, Meredith ;

Antonazzi, Marco ;

Shanahan, Catherine M. .

AGING-US, 2023, 15 (05) :1232-1234

[18] Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity [J].

Falker, Clemens ;

Hartmann, Alexander ;

Guett, Inga ;

Dohler, Frank ;

Altmeppen, Hermann ;

Betzel, Christian ;

Schubert, Robin ;

Thurm, Dana ;

Wegwitz, Florian ;

Joshi, Pooja ;

Verderio, Claudia ;

Krasemann, Susanne ;

Glatzel, Markus .

JOURNAL OF NEUROCHEMISTRY, 2016, 137 (01) :88-100

[19] Cells release prions in association with exosomes [J].

Fevrier, B ;

Vilette, D ;

Archer, F ;

Loew, D ;

Faigle, W ;

Vidal, M ;

Laude, H ;

Raposo, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9683-9688

[20] Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation [J].

Froehlich, Dominik ;

Kuo, Wen Ping ;

Fruehbeis, Carsten ;

Sun, Jyh-Jang ;

Zehendner, Christoph M. ;

Luhmann, Heiko J. ;

Pinto, Sheena ;

Toedling, Joern ;

Trotter, Jacqueline ;

Kraemer-Albers, Eva-Maria .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2014, 369 (1652)

← 1 2 3 4 5 6 7 8 →