PEPTIDE-BASED ANTIFUNGAL THERAPIES AGAINST EMERGING INFECTIONS

被引：124

作者：

Matejuk, A. ^{[1
]}

Leng, Q. ^{[1
]}

Begum, M. D. ^{[1
]}

Woodle, M. C. ^{[2
]}

Scaria, P. ^{[2
]}

Chou, S. -T ^{[1
]}

Mixson, A. J. ^{[1
]}

机构：

[1] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA

[2] Aparna Biosci Corp, Rockville, MD 20852 USA

来源：

DRUGS OF THE FUTURE | 2010年 / 35卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CATIONIC ANTIMICROBIAL PEPTIDES; HISTIDINE-RICH POLYPEPTIDES; HUMAN NEUTROPHIL DEFENSINS; CANDIDA-ALBICANS; IN-VITRO; BETA-DEFENSIN; HOST-DEFENSE; ANTIBACTERIAL PEPTIDES; ASPERGILLUS-FUMIGATUS; HUMAN BETA-DEFENSIN-2;

D O I：

10.1358/dof.2010.035.03.1452077

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acquired drug resistance to mycotic infections is rapidly emerging as a major medical problem. Opportunistic fungal infections create therapeutic challenges, particularly in high-risk immunocompromised patients with AIDS, cancel; and those undergoing transplantation. Higher mortality and/or morbidity rotes due to invasive mycosis have been increasing over the last 20 years, and in light of growing resistance to commonly used antibiotics, novel antifungal drugs and approaches are required. Currently, there is considerable interest in antifungal peptides that are ubiquitous in plant and animal kingdoms. These small cationic peptides may have specific targets or may be multifunctional in their mechanism of action. On the basis of recent advances in protein engineering and solid-phase syntheses, the utility and potential of selected peptides as efficient antifungal drugs with acceptable toxicity profiles are being realized. This review will discuss recent advances in peptide therapy for opportunistic fungal infections.

引用

页码：197 / 217

页数：21

共 287 条

[11] The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5 [J].